In this study, the response surface methodology was first applied to optimize the photocatalytic degradation of styrene in aqueous phase under UV/TiO 2 system. Twenty experiments were done by adjusting three parameters (styrene concentration, TiO 2 dose, and pH) at five levels. Optimal experimental conditions for arbitrary aqueous styrene concentration (115 mg L À1 ) were found: initial pH 7 and TiO 2 loading 2 g L À1 with photocatalytic degradation efficiency of 79.2%. Furthermore, the main degradation intermediate produced was identified by GC/MS. The total organic carbon results revealed that the photocatalysis process could be effectively mineralized. Kinetics of the photocatalytic reaction followed a pseudo-first-order model.