Photoactive electrospun cellulose acetate/polyethylene oxide/methylene blue and trilayered cellulose acetate/polyethylene oxide/silk fibroin/ciprofloxacin nanofibers for chronic wound healing

Khalek, Mohamed Abdel; Gaber, Sara A. Abdel; El-Domany, Ramadan A.; El‐Kemary, Maged

doi:10.1016/j.ijbiomac.2021.11.012

Cited by 37 publications

(16 citation statements)

References 117 publications

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“…of these drugs (Table 4). 10,111,[115][116][117][118][119][120][121][122][123][124][125][126][127][128][129][130][131] Curcumin is a natural polyphenol obtained from turmeric. 132 This natural bio-substance is often used as an antioxidant and anti-inflammatory agent, and can aid various stages of the wound healing process.…”

Section: Drugsmentioning

confidence: 99%

Recent Advances in Nano-Drug Delivery Systems for the Treatment of Diabetic Wound Healing

Liu¹,

Wei²,

Zheng³

et al. 2023

IJN

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Diabetes mellitus (DM) induced wound healing impairment remains a serious health problem and burden on the clinical obligation for high amputation rates. Based on the features of wound microenvironment, biomaterials loading specific drugs can benefit diabetic wound treatment. Drug delivery systems (DDSs) can carry diverse functional substances to the wound site. Nano-drug delivery systems (NDDSs), benefiting from their features related to nano size, overcome limitations of conventional DDSs application and are considered as a developing process in the wound treatment field. Recently, a number of finely designed nanocarriers efficiently loading various substances (bioactive and non-bioactive factors) have emerged to circumvent constraints faced by traditional DDSs. This review describes various recent advances of nano-drug delivery systems involved in mitigating diabetes mellitus-based nonhealing wounds.

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Section: Drugsmentioning

confidence: 99%

Recent Advances in Nano-Drug Delivery Systems for the Treatment of Diabetic Wound Healing

Liu¹,

Wei²,

Zheng³

et al. 2023

IJN

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“…The nanofibers could produce ROS after light irradiation at 635 nm, accelerating the healing of infectious wounds by inhibiting S. aureus, K. pneumoniae , and P. aeruginosa biofilms. 213 Zhang et al developed a hybrid hydrogel with MnO 2 nanosheets. The injectable MnO 2 nanosheet hydrogel could perform thermogenesis under 808-nm laser irradiation, eliminating ROS and inflammation and promoting wound repair.…”

Section: Nanoplatforms For Chronic Wound Healingmentioning

confidence: 99%

Nanobiotechnology: Applications in Chronic Wound Healing

Jiang¹,

Li²,

Qiu³

et al. 2022

IJN

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Wounds occur when skin integrity is broken and the skin is damaged. With progressive changes in the disease spectrum, the acute wounds caused by mechanical trauma have been become less common, while chronic wounds triggered with aging, diabetes and infection have become more frequent. Chronic wounds now affect more than 6 million people in the United States, amounting to 10 billion dollars in annual expenditure. However, the treatment of chronic wounds is associated with numerous challenges. Traditional remedies for chronic wounds include skin grafting, flap transplantation, negative-pressure wound therapy, and gauze dressing, all of which can cause tissue damage or activity limitations. Nanobiotechnology — which comprises a diverse array of technologies derived from engineering, chemistry, and biology — is now being applied in biomedical practice. Here, we review the design, application, and clinical trials for nanotechnology-based therapies for chronic wound healing, highlighting the clinical potential of nanobiotechnology in such treatments. By summarizing previous nanobiotechnology studies, we lay the foundation for future wound care via a nanotech-based multifunctional smart system.

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“…Thus, the combination of PDT and antibiotic could be achieved by sequentially applying MB‐loaded nanofibers then Cipro‐loaded ones to the same wound, allowing to overcome drug–drug interaction problems reported in cases of coloading in the same dressing and to allow different administration times. [ 18 ]…”

Section: Biodegradable Electrospun Nanofibers As Drug Delivery System...mentioning

confidence: 99%

“…PDT also offers advantages in this field as it is a multitarget mechanism, which means that the produced ROS will affect multiple targets within microbial cells, instead of working on a one‐target principle, which generally happens with conventional antimicrobials. [ 16–18 ]…”

Section: Introductionmentioning

confidence: 99%

Drug Delivery Systems for Photodynamic Therapy: The Potentiality and Versatility of Electrospun Nanofibers

Costa

Fangueiro

Ferreira

2022

Macromolecular Bioscience

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Recently, photodynamic therapy (PDT) has become a promising approach for the treatment of a broad range of diseases, including oncological and infectious diseases. This minimally invasive and localized therapy is based on the production of reactive oxygen species able to destroy cancer cells and inactivate pathogens by combining the use of photosensitizers (PSs), light, and molecular oxygen. To overcome the drawbacks of drug systemic administration, drug delivery systems (DDS) can be used to carrier the PSs, allowing higher therapeutic efficacy and minimal toxicological effects. Polymeric nanofibers produced by electrospinning emerged as powerful platforms for drug delivery applications. Electrospun nanofibers exhibit outstanding characteristics, such as large surface‐area‐to‐volume ratio associated with high drug loading, high porosity, flexibility, ability to incorporate and release a wide variety of therapeutic agents, biocompatibility, and biodegradability. Due to the versatility of this technique, fibers with different morphologies and functionalities, including drug release profile can be produced. The possibility of scalability makes electrospinning even more attractive for the development of DDS. This review aims to explore and show an up to date of the huge potential of electrospun nanofibers as DDS for different PDT applications and discuss the opportunities and challenges in this field.

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Photoactive electrospun cellulose acetate/polyethylene oxide/methylene blue and trilayered cellulose acetate/polyethylene oxide/silk fibroin/ciprofloxacin nanofibers for chronic wound healing

Cited by 37 publications

References 117 publications

Recent Advances in Nano-Drug Delivery Systems for the Treatment of Diabetic Wound Healing

Recent Advances in Nano-Drug Delivery Systems for the Treatment of Diabetic Wound Healing

Nanobiotechnology: Applications in Chronic Wound Healing

Drug Delivery Systems for Photodynamic Therapy: The Potentiality and Versatility of Electrospun Nanofibers

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