volume 09, issue 01n02, P1940005 2019
DOI: 10.1142/s1793984419400051
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Abstract: The peroxidase-like functionality of iron oxide (IO) nanoparticles has attracted substantial attention in cancer treatment by reactive oxygen species (ROS) catalytic over-generation. However, the inefficient intracellular ROS generation still hurdles ready-to-use application of IO nanoparticles, attributing to the transient lifetime and limited diffusion distance of ROS. Indeed, excessive ROS generation in mitochondria is desirable to enhance cell death against cancer cells. In this study, we designed zinc-do…

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