Photo(chemo)therapy for vitiligo

Pacifico, Alessia; Leone, Giovanni

doi:10.1111/j.1600-0781.2011.00606.x

Cited by 66 publications

(60 citation statements)

References 139 publications

(156 reference statements)

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“…Comparing the use narrowband UVB and PUVA in vitiligo patients, narrow-band UVB was found to be more effective along with a lower side effect profile compared to local PUVA. Therefore, narrow-band UVB is considered to be one of the first options in vitiligo treatment (10). Narrow-band UVB therapy is also effectively used in mycosis fungoides.…”

Section: Resultsmentioning

confidence: 99%

Our Experience with Narrow-Band UVB for 15 Years: A Retrospective Study of 205 Patients

2015

J Turgut Ozal Med Cent

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Aim: Widely used in many indications in dermatology practice, narrow-band ultraviolet B is a kind of ultraviolet with a wavelength usually condensing at 312nm. Our aim in this study is to introduce our 15-year experience with narrow-band UVB on 205 patients. Materials and Methods: Gender, diagnosis, distribution of lesions, beginning dose, maximum dose, number of sessions, and cumulative dose of patients treated with narrow band UVB were retrospectively studied. Results: The mean age of patients was 37,2 years. 44,4% of the patients was males, 55,6% was females. 34,1% of the patients were diagnosed with psoriasis and 14,6% of the patients with mycosis fungoides. 73,7% of distribution of lesions was diffused, 28% was central, and 26% was peripheral. The mean number of sessions was 27,1 and the mean cumulative dose was 21070 mJ/cm 2 in the first treatment. The mean starting dose was 125,4 mJ/cm 2 and the mean maximum dose was 21070 mJ/cm 2 . Conclusion: Differences between the means of the number of sessions, maximum doses, cumulative doses, and diseases were statistically significant. Key Words: Mycosis Fungoides; Narrow Band UVB; Phototherapy; Psoriasis.15 Yıllık Dar Bant UVB Deneyimi: 205 Hastanın Retrospektif İncelenmesi Özet Amaç: Dermatoloji pratiğinde birçok endikasyonda kullanım alanı bulan dar bant ultraviyole B, dalga boyu genellikle 312nm'de yoğunlaşmış bir ultraviyole B türüdür. Bu çalışmadaki amacımız, 205 hastamızı içeren 15 yıllık dar bant UVB deneyimimizi ortaya koymaktır. Gereç ve Yöntem: Dar bant UVB tedavisi alan hastaların yaşı, cinsiyeti, tanısı, lezyonlarının yerleşim yeri, başlangıç dozu, maksimum dozu, seans sayısı ve toplamda aldığı doz retrospektif olarak değerlendirildi. Bulgular: Hastaların yaş ortalaması 37,2 yıldı. Hastaların %44,4'ü erkek, %55,6'sı kadındı. Hastaların %34,1'i psoriazis ve %14,6'sı mikozis fungoides tanısı almıştı. Lezyonların %73,7'si diffüz, %28'i santral, %26'sı ise periferik yerleşim gösteriyordu. İlk tedavi periyodundaki ortalama seans sayısı 27,1, toplam doz ortalaması ise 21070 mJ/cm 2 idi. Başlangıç dozu ortalaması 125,4 mJ/cm 2 , maksimum doz ortalaması 1463mJ/cm 2 olarak saptandı. Sonuç: Hastalıklar ile ortalama seans sayıları, maksimum doz ve toplam doz arasındaki farklar istatiksel olarak anlamlıydı.

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Section: Resultsmentioning

confidence: 99%

Our Experience with Narrow-Band UVB for 15 Years: A Retrospective Study of 205 Patients

2015

J Turgut Ozal Med Cent

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“…Doz, vitiligolu deride asemptomatik pembe eritem oluşana kadar, her seans %10-20 oranında artırılır. Deri tipi 1-2'de %10-20, 3'de %30, 4'de ise %40 doz artışı stratejisini öneren bir görüş de bulunmaktadır (7). Seans başına uygulanabilecek maksimum doz kişiler arasında büyük farklılıklar göstermektedir.…”

Section: Vitiligoda Fototerapiunclassified

“…Platoyu görebilmek için de lezyonları periyodik olarak fotoğraflamak gereklidir. Tedavinin ilk üç ayı içinde hiç repigmentasyon yoksa veya altı ay sonunda %25'ten az repigmentasyon sağlandıysa dar bant UVB'nin kesilmesi önerilmektedir (7).…”

Section: Vitiligoda Fototerapiunclassified

“…Ancak, yapılan bir çalışmada, topikal takrolimus ve pimekrolimusun UV ile indüklenen timin dimerleri oluşumunu inhibe ettikleri gösterilmiştir (28). Yine de, uzun dönemde ortaya çıkabilecek yan etkileri tam olarak ekarte edebilmek için daha çok çalışmaya ihtiyaç olduğu, mevcut verilerle bu kombinasyonun rutin olarak önerilmemesi gerektiği vurgulanmaktadır (7). Fototerapi ünitemizdeki yaklaşımımız, tek başına dar bant UVB ya da excimer ışık ile yeterli süre tedaviye rağmen (yaklaşık olarak üç-dört ay) istenen yanıt elde edilemeyen hastalarda, fototerapiyi takrolimus/pimekrolimus ile kombine etmek şeklindedir.…”

Section: Vitiligoda Fototerapiunclassified

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Current Approach to Phototherapy Applications in Dermatology Practice: Part 2. Phototherapy in Vitiligo, Mycosis Fungoides, Atopic Dermatitis, Sclerosing Diseases and Psoriasis

Gençosmanoğlu¹

2017

tdd

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“…An alternative for PUVA therapy is narrowband ultraviolet B (NB-UVB) phototherapy using lamps that have a maximum emission at 311-312 nm and is now considered as the 'gold standard' for the treatment of diffuse vitiligo. The treatment with two recently introduced UVB sources that emit 308 nm wavelengths, the 308 nm xenon chloride (XeCl) excimer laser and the 308 nm XeCl excimer light, has also been reported to be effective and might be the treatment of choice for localized disease: this treatment modality has been defined as 'targeted phototherapy' [2], all aiming at sparing the unaffected skin undue radiation exposure.…”

Section: Introductionmentioning

confidence: 99%

Phototherapy in vitiligo

El‐Mofty¹,

Mostafa²,

Esmat³

et al. 2012

Journal of the Egyptian Womenʼs Dermatologic Society

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Phototherapy is the backbone of vitiligo treatment. Besides the use of heliotherapy since ancient times, artificial sources have been introduced for the last decades in different wavelengths and administration devices utilizing a multitude of regimens and treatment combinations. In this article, we present a comprehensive compilation of the use of different modalities of phototherapy in vitiligo on the basis of a multitude of related comparative studies that have been carried out during the last decade, including those performed at the Phototherapy Unit, Kasr Al Aini Hospital. The phototherapeutic modality most commonly utilized in the treatment of vitiligo at present is narrowband ultraviolet B (NB-UVB) (311 nm), although in our area, photochemotherapy still continues to be used. Efforts have been made to take into account most comparative studies including the different combinations of NB-UVB with other modalities. The different types of psoralens used in photochemotherapy are discussed, besides comparison of the use of various ultraviolet light sources in vitiligo. The results of studies comparing both psoralen plus ultraviolet A and NB-UVB are also included. A more recently emerging phototherapeutic modality in the treatment of vitiligo and other photoresponsive dermatoses is broadband UVA, which awaits shortterm and long-term safety evaluation studies, both clinical and laboratory. Diverse tools yielding targeted phototherapy are widely being used nowadays in the treatment of vitiligo. Systems range from laser to incoherent pointed light equipment to larger but localized sources, all aiming at sparing the unaffected skin undue radiation exposure.

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Photo(chemo)therapy for vitiligo

Cited by 66 publications

References 139 publications

Our Experience with Narrow-Band UVB for 15 Years: A Retrospective Study of 205 Patients

Our Experience with Narrow-Band UVB for 15 Years: A Retrospective Study of 205 Patients

Current Approach to Phototherapy Applications in Dermatology Practice: Part 2. Phototherapy in Vitiligo, Mycosis Fungoides, Atopic Dermatitis, Sclerosing Diseases and Psoriasis

Phototherapy in vitiligo

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