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Cited by 9 publications
(6 citation statements)
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References 47 publications
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“…Proteomic studies of oxidative stress-based models have demonstrated that different levels of ROS induce distinct phosphorylation patterns at different sites, determining the kinase activities and phosphatase regulation involved in DNA processing and cell cycle control (low levels of H 2 O 2 ) or cell survival response (high levels of H 2 O 2 ) [139]. Higher levels of ROS lead to the expressive activation of antioxidant enzymes and metabolic alterations.…”
Section: Extracellular Vesicles (Evs)mentioning
confidence: 99%
“…Proteomic studies of oxidative stress-based models have demonstrated that different levels of ROS induce distinct phosphorylation patterns at different sites, determining the kinase activities and phosphatase regulation involved in DNA processing and cell cycle control (low levels of H 2 O 2 ) or cell survival response (high levels of H 2 O 2 ) [139]. Higher levels of ROS lead to the expressive activation of antioxidant enzymes and metabolic alterations.…”
Section: Extracellular Vesicles (Evs)mentioning
confidence: 99%
“…Moreover, ROS are produced by oxidase enzymes, which are essential to the immune system response against a pathogen. Proteomic studies in P. lutzii have demonstrated that various proteins involved in oxidative stress are differentially expressed according to different concentrations of H 2 O 2 exposure (de Arruda et al, 2013), and different concentrations of H 2 O 2 lead to differentiated patterns of phosphorylation in P. brasiliensis, which determines different responses, that is, survival or cell death (Chaves et al, 2017).…”
Section: Introductionmentioning
confidence: 99%
“…Paracoccidioides brasiliensis is a facultative intracellular pathogen able to survive and replicate in macrophages (Chaves et al . ). In this study, it was demonstrated that cytochalasin E decreased phagocytosis by macrophages.…”
Section: Discussionmentioning
confidence: 97%