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Cited by 16 publications
(18 citation statements)
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References 78 publications
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“…[13,62,100]. Capture DA9 and Europium-labeled detection 77G7 monoclonal antibodies used in these assays have linear (not conformational) epitopes and detect only open (unfolded) conformers of monomeric tau as outlined inFig.…”
mentioning
confidence: 99%
“…[13,62,100]. Capture DA9 and Europium-labeled detection 77G7 monoclonal antibodies used in these assays have linear (not conformational) epitopes and detect only open (unfolded) conformers of monomeric tau as outlined inFig.…”
mentioning
confidence: 99%
“…According to Luna-Muñoz and collaborators, at least five different events take place in the “pre-tangle” stage: 1) C-terminal truncation of tau species (Glu-391); 2) a cascade of specific phosphorylations of tau protein in the N-terminus; 3) C-terminal truncation by the action of caspase-3; 4) oligomerization and aggregation of tau; and 5) assembly of tau into PHF (Luna-Muñoz et al, 2013; reviewed in Šimić et al, 2016). However, which form of tau is the most toxic (aggregated misfolded/fibrillar, soluble hyperphosphorylated/mislocalized, or both) and whether that toxicity represents a gain or loss of function continues to be debated.…”
Section: Clinical and Neuropathological Criteria For Ad Diagnosismentioning
confidence: 99%
“…The htau 441 isoform consists of four conserved microtubule‐binding repeats (MTRs‐R1: Gln244‐Lys274, R2: Val275‐Ser305, R3: Val306‐Gln336, and R4:Val337‐Asn368) within the microtubule‐binding domain (MBD) near the C‐terminus, a C‐terminal domain, a projection domain in the N‐terminal region consisting of 2 inserts (I1: Gly45‐Asp74 and I2: Asp74‐Ala103) and a proline‐rich region (PRR) connecting these domains (Fig. ) …”
Section: Introductionmentioning
confidence: 99%
“…1). 4 The level of phosphorylation for regular neuronal function in a healthy brain has been quantitatively defined as 2-3 moles of phosphate per mole of htau 441 . 5…”
Section: Introductionmentioning
confidence: 99%