Phosphorylated isoforms of insulin-like growth factor binding protein-1 in the cervix as a predictor of cervical ripeness

Nuutila, Mika; Hiilesmaa, Vilho; Kärkkäinen, Tytti; Ylikorkala, Olavi; Rutanen, Eeva‐Marja

doi:10.1016/s0029-7844(99)00321-x

Cited by 46 publications

(53 citation statements)

References 24 publications

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“…Biochemical markers, such as fetal fibronectin and IGFBP-1,have also been studied, but neither have shown to be superior to the Bishop score regarding the prediction of successful IOL [44,45,46]. …”

Section: Resultsmentioning

confidence: 99%

Definition of Failed Induction of Labor and Its Predictive Factors: Two Unsolved Issues of an Everyday Clinical Situation

et al. 2015

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Objective: The objectives of this review were to identify the predictive factors of induction of labor (IOL) failure or success as well as to highlight the current heterogeneity regarding the definition and diagnosis of failed IOL. Materials and Methods: Only studies in which the main or secondary outcome was failed IOL, defined as not entering the active phase of labor after 24 h of prostaglandin administration ± 12 h of oxytocin infusion, were included in the review. The data collected were: study design, definition of failed IOL, induction method, IOL indications, failed IOL rate, cesarean section because of failed IOL and predictors of failed IOL. Results: The database search detected 507 publications. The main reason for exclusion was that the primary or secondary outcomes were not the predetermined definition of failed IOL (not achieving active phase of labor). Finally, 7 studies were eligible. The main predictive factors identified in the review were cervical status, evaluated by the Bishop score or cervical length. Discussion: Failed IOL should be defined as the inability to achieve the active phase of labor, considering that the definition of IOL is to enter the active phase of labor. A universal definition of failed IOL is an essential requisite to analyze and obtain solid results and conclusions on this issue. An important finding of this review is that only 7 of all the studies reviewed assessed achieving the active phase of labor as a primary or secondary IOL outcome. Another conclusion is that cervical status remains the most important predictor of IOL outcome, although the value of the parameters explored up to now is limited. To find or develop predictive tools to identify those women exposed to IOL who may not reach the active phase of labor is crucial to minimize the risks and costs associated with IOL failure while opening a great opportunity for investigation. Therefore, other predictive tools should be studied in order to improve IOL outcome in terms of health and economic burden.

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Section: Resultsmentioning

confidence: 99%

Definition of Failed Induction of Labor and Its Predictive Factors: Two Unsolved Issues of an Everyday Clinical Situation

et al. 2015

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“…Some biochemical markers have also been reported as being useful in the prediction of a successful induction of labor. These include fetal fibronectin and insulin‐like growth factor binding protein 1 . Studies published until now did not find any of them to be superior to clinical evaluation, thus further studies might be needed.…”

Section: Discussionmentioning

confidence: 99%

Value of Bishop score and ultrasound cervical length measurement in the prediction of cesarean delivery

Cubal

Carvalho

Ferreira

et al. 2013

J of Obstet and Gynaecol

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“…A bedside test for phosphorylated isoforms of insulin‐like growth factor binding protein‐1 (IGFBP‐1) has been suggested to predict success of labor induction (5). Phosphorylated isoforms of IGFBP‐1, different from those found in amniotic fluid, are produced by decidual cells and are presented in the cervical secretion of women with intact fetal membranes.…”

Section: Introductionmentioning

confidence: 99%

Cervical insulin‐like growth factor binding protein‐1 (IGFBP‐1) to predict spontaneous onset of labor and induction to delivery interval in post‐term pregnancy

Dögl

Skogvoll

Heimstad

2010

Acta Obstet Gynecol Scand

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Phosphorylated isoforms of insulin-like growth factor binding protein-1 in the cervix as a predictor of cervical ripeness

Abstract: Phosphorylated isoforms of IGFBP-1, different from those in AF, are present in the cervical secretion of women with intact fetal membranes and reflect cervical ripeness. A bedside test for those IGFBP-1 isoforms might help in predicting amenability for labor induction.

Cited by 46 publications

References 24 publications

Definition of Failed Induction of Labor and Its Predictive Factors: Two Unsolved Issues of an Everyday Clinical Situation

Definition of Failed Induction of Labor and Its Predictive Factors: Two Unsolved Issues of an Everyday Clinical Situation

Value of Bishop score and ultrasound cervical length measurement in the prediction of cesarean delivery

Cervical insulin‐like growth factor binding protein‐1 (IGFBP‐1) to predict spontaneous onset of labor and induction to delivery interval in post‐term pregnancy

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