Phosphorylated ATM and H2AX in T and B lymphocytes from rats with moderate and severe malnutrition

González-Gutiérrez, Ana María; Ortiz-Muñiz, Rocío; Garcia‐Rodriguez, María del Carmen; Cortés-Barberena, Edith

doi:10.1016/j.dnarep.2019.102640

Cited by 7 publications

(5 citation statements)

References 48 publications

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“…Similar to the affected generation, the offspring whose parents had experienced famine during flight showed an increased T2D prevalence, which was not statistically significant. Malnutrition represents a burden that influences the T2D risk of the offspring through complex and individual mechanisms (11,64,65). However, most of the literature so far has focused on the influence of parental undernutrition in utero on the development of T2D in the offspring later in life, although there are already data suggesting that conditions in utero also depend on behaviors and conditions that exist before the onset of pregnancy (66).…”

Section: Discussionmentioning

confidence: 99%

The Impact of Childhood Traumatization on Diabetes Mellitus Type 2 Risk in World War II Refugees and Their Offspring

Wildenberg¹,

Zillich

Streit

et al. 2023

Psychosom Med

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Objective Type 2 diabetes mellitus (T2D) is a chronic disease that is influenced by different factors. The extent to which degree adverse childhood events (ACEs) can modify the potential to development of T2D is still not explored and therefore represents one of the central questions of the childhood escape–late life outcome (DRKS00012419) study. In addition, transgenerational effects were considered in the analyses. Methods The study analyzed the association of self-reported traumatic experiences and T2D disease of refugees from East Prussia, who were displaced from their former homeland at the end of the World War II. In addition, an independent sample consisting of participants of first-generation offspring of refugees was analyzed. Results Of the 242 refugees, all aged between 73 and 93 years, 17.36% reported T2D disease, whereas among the offspring (n = 272), aged between 47 and 73 years, it was 5.5%, meaning reduced T2D prevalence for both generations compared with the German population of comparable age. In the refugee generation, emotional neglect showed a negative association with development of T2D in later life. In women, separation from close caregivers in childhood showed a negative association with later T2D. In contrast, experiencing emotional abuse in childhood showed a positive association with later T2D. The offspring generation showed no associations of adverse childhood events and reported T2D diagnoses in later life. Conclusions Our results demonstrate that individual trauma in childhood is responded to with different mechanisms that can lead to both increased and decreased reported T2D diagnoses in adulthood and thus should by no means be considered in a generalized manner.

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Section: Discussionmentioning

confidence: 99%

The Impact of Childhood Traumatization on Diabetes Mellitus Type 2 Risk in World War II Refugees and Their Offspring

Wildenberg¹,

Zillich

Streit

et al. 2023

Psychosom Med

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“…We compared the presenting symptoms and outcomes of these 27 women with the observations of Sheehan and Ironside made in 1939 and found remarkable similarities. They concluded thiamin alone may not resolve HG‐WE, and we have offered potential explanations for thiamin failure in the following list 53–55,83,99–105 : Inadequate magnesium to facilitate phosphorylation of thiamin‐to‐TPP 53–55 …”

Section: Discussionmentioning

confidence: 99%

“…">Inadequate glucose, protein, and requisite vitamins and minerals 83 Depleted carrier proteins because of gestational malnutrition 99,100 The size of the enlarged ventricles exceeding the ability for thiamin to be effective 101 …”

Section: Discussionmentioning

confidence: 99%

Gestational malnutrition, hyperemesis gravidarum, and Wernicke's encephalopathy: What is missing?

Erick

2022

Nut in Clin Prac

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Hyperemesis gravidarum (HG), or the severe nausea and vomiting of pregnancy, is one of the most dreaded complications of gestation, affecting between 1.5% and 3.0% of pregnant women. From the late 1800s to the mid-1980s, the etiology was frequently cited to have psychological and/or-laterperhaps hormonal origins, which have numbered at least 10. Current research has unearthed a genetic basis for HG that implicates growth differentiation factor 15, insulin-like growth factor binding protein 7, and hormone receptors (namely, glial cell line-derived neurogenic factor family receptor alpha-like and the progesterone receptor). Whatever the origins of this disease, it has caused immeasurable physiological and psychological damage to women, their fetuses, and their families. The psychological trauma includes a high rate of suicidal ideation as well as posttraumatic stress disorder. Whereas the healthcare costs are substantial for the mother with HG, the lifetime costs to the neonate include that which accompanies reduced employment earnings related to cognitive compromise. Another devastating outcome of severe HG can be Wernicke's encephalopathy (WE), which has a high fetal and maternal mortality rate. Our study explored 18 current reports of HG and WE. We highlighted additional presenting features we believe also accompany, and sometimes replace, the classically taught triad components of WE: ataxia, confabulation, and nystagmus. We agree with the conclusion made by Sheehan and Ironside in 1939 that thiamin alone may not reverse WE, and we offer possible explanations. Lastly, we offer suggestions for remediation.

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“…This raise the question -did the malnutrition affect the B cells in ltration in CRC or did B cells worsen the malnutrition status? B cells have been demonstrated as an essential factor associated with malnutrition [23,24]. Previous research showed under anorexia nervosa, increased number of B lymphocyte associated with body mass loss drives the relative lymphocytosis, leading to the poor outcome [25].…”

Section: Discussionmentioning

confidence: 99%

Malnutrition Accelerates Colorectal Cancer Progression through Macrophage Activated by B Cells Immune via Gut Microbiota

Xu¹,

Li²,

Wang³

et al. 2020

Preprint

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Background: Malnutrition threatened the clinical outcomes of colorectal cancer (CRC) by reducing patients’ responses to anti-cancer treatments and ultimately shortening thesurvival time. Recently malnutrition has been confirmed to play an important role in CRC progress via gut microbiota. However, roles of gut microbiota in the immunopathogenesis of malnutrition and its underlying mechanisms remain inconclusive. Methods: Patient-Generated Subjective Global Assessment (PG-SGA) was performed to determine the nutrition status in colon cancer patients. 16srRNA sequencing was prepared to explore the dramatic variation of the fecal microbiota among patients with different nutrition status. Fecal microbiota transplantation was used to transplant into C57BL/6J mice model and DSS/AOM mice model. Immunohistochemistry and immunofluorescence were applied to test the CD makers. Fluorescence-activated cell sorting was also prepared to explore the B cells and macrophage from serum and tissues. Enzyme-linked immunosorbent assay and qPCR were used to determine the expression level of cytokines.Results: In this work, we found the specific microbiota species including Atopobium.vaginae, Selenomonas.sputigena and Faecalibacterium.prausnitzii, which may be considered as the diagnostic biomarkers to help improve poor prognosis in CRC. These microbiota were found to be protumorigenic and adversely affect the nutritional status and overall survival of the animal models. More importantly, our evidence suggesting that these fecal microbiota recruited B cells and macrophage to activate the specific tumor immune in CRC. Depletion of B cells significantly suppressed fecal microbiota induced-M2b polarization, as well as the protumorigenic activity of tumor-associated macrophages in vivo.Conclusion: gut microbiome in CRC under malnutrition status could upregulate the activity of B cells and protumorigenic macrophage in CRC. Gut microbiome intervention could be a feasible approach to malnutrition-related CRC treatment.

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Phosphorylated ATM and H2AX in T and B lymphocytes from rats with moderate and severe malnutrition

Cited by 7 publications

References 48 publications

The Impact of Childhood Traumatization on Diabetes Mellitus Type 2 Risk in World War II Refugees and Their Offspring

The Impact of Childhood Traumatization on Diabetes Mellitus Type 2 Risk in World War II Refugees and Their Offspring

Gestational malnutrition, hyperemesis gravidarum, and Wernicke's encephalopathy: What is missing?

Malnutrition Accelerates Colorectal Cancer Progression through Macrophage Activated by B Cells Immune via Gut Microbiota

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