“…Transmethylation is one of the 2 pathways for the formation of phosphatidylcholine, proceeding by successive steps of enzymatic transfer of methyl-groups to phosphatidylethanolarnine from the donor S-adenosylmethionine (AdoMet), to yield the final product via mono-and di-methylated intermediates [8][9][10][11]. The evidence for the hypothesis that this transmethylation is involved in linking receptor signals to cellular responses is derived from experiments showing that phospholipid methylation led to increased membrane fluidity [12], that the various kinds of cell activation were associated with methylation of phosphatidylethanolamine [1][2][3][4][5][6], and that some of these processes could be blocked by the use of methyltransferase inhibitors [4][5][6]13]. Still the Abbreviations: AdoMet, S-adenosyl-L-methionine; Hey, homocysteine; AdoHcy, S-adenosyl-L-homocysteine; c3Ado, 3-deazaadenosine; c3AdoHcy, S-3-deazaadenosyl-L-homoeysteine; PuoHcy, a purine nucleoside analogue of AdoHcy; MIX, l-methyl-3-isobutylxanthine; Hepes, 4(2-hydroxyethyl)-1-piperazineethanesulfonic acid * To whom correspondence should be addressed causal relationship between these phenomena may be questioned [ 14,15].…”