1980
DOI: 10.1126/science.6157192
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Abstract: Many types of cells methylate phospholipids using two methyltransferase enzymes that are asymmetrically distributed in membranes. As the phospholipids are successively methylated, they are translocated from the inside to the outside of the membrane. When catecholamine neurotransmitters, lectins, immunoglobulins or chemotaxic peptides bind to the cell surface, they stimulate the methyltransferase enzymes and reduce membrane viscosity. The methylation of phospholipids is coupled to Ca2+ influx and the release of… Show more

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Cited by 1,070 publications
(243 citation statements)
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“…However, it will serve our pre s ent discussion better if we consider another stimulus-induced membrane perturb ation, one that has been ad mirably worked out in Axelrod's labo ratory (see Hirata and Axelrod, 1980). Figure 5 summarizes the events proposed.…”
Section: Membrane Phos Pholip Ids and Cell Activitymentioning
confidence: 99%
“…However, it will serve our pre s ent discussion better if we consider another stimulus-induced membrane perturb ation, one that has been ad mirably worked out in Axelrod's labo ratory (see Hirata and Axelrod, 1980). Figure 5 summarizes the events proposed.…”
Section: Membrane Phos Pholip Ids and Cell Activitymentioning
confidence: 99%
“…A number of acidic lipids available in our laboratory were compared with the unknown compound for Rr-values in HPTLC ( fig.4) but none of them proved to be identical. The possibility that the substance was one of the intermediates in the methylation of phosphatidylethanolamine during formation of phosphatidylcholine was also investigated [12]. This was found not to be the case judging from identity in HPTLC, in the solvent system chloroform-propionic acid-n-propanolwater, 2 : 2 : 3 : 1.…”
Section: Chromatographic Investigations In Relationmentioning
confidence: 99%
“…Phospholipid methylation has been implicated in the transduction through plasma membranes of a variety of receptor-mediated signals [ 1 ], including activation of adenylate cyclase by isoprenaline [2,3], lectin-induced formation of arachidonic acid, Ca 2÷-influx and mitogenesis [4,5], antigen-stimulated histamine release [4,6], and response to chemoattractrants [1,7]. Transmethylation is one of the 2 pathways for the formation of phosphatidylcholine, proceeding by successive steps of enzymatic transfer of methyl-groups to phosphatidylethanolarnine from the donor S-adenosylmethionine (AdoMet), to yield the final product via mono-and di-methylated intermediates [8][9][10][11].…”
Section: Introductionmentioning
confidence: 99%
“…Transmethylation is one of the 2 pathways for the formation of phosphatidylcholine, proceeding by successive steps of enzymatic transfer of methyl-groups to phosphatidylethanolarnine from the donor S-adenosylmethionine (AdoMet), to yield the final product via mono-and di-methylated intermediates [8][9][10][11]. The evidence for the hypothesis that this transmethylation is involved in linking receptor signals to cellular responses is derived from experiments showing that phospholipid methylation led to increased membrane fluidity [12], that the various kinds of cell activation were associated with methylation of phosphatidylethanolamine [1][2][3][4][5][6], and that some of these processes could be blocked by the use of methyltransferase inhibitors [4][5][6]13]. Still the Abbreviations: AdoMet, S-adenosyl-L-methionine; Hey, homocysteine; AdoHcy, S-adenosyl-L-homocysteine; c3Ado, 3-deazaadenosine; c3AdoHcy, S-3-deazaadenosyl-L-homoeysteine; PuoHcy, a purine nucleoside analogue of AdoHcy; MIX, l-methyl-3-isobutylxanthine; Hepes, 4(2-hydroxyethyl)-1-piperazineethanesulfonic acid * To whom correspondence should be addressed causal relationship between these phenomena may be questioned [ 14,15].…”
Section: Introductionmentioning
confidence: 99%