Phospholipase C ε‑1 gene polymorphisms and prognosis of esophageal cancer patients from a high‑incidence region in northern China

Abstract

Abstract. Recent genome-wide association studies identified susceptibility loci for esophageal squamous cell carcinoma (ESCC), the most common histological type of esophageal cancer, in the phospholipase C ε-1 gene (PLCE1). The aim of the present study was to investigate whether polymorphisms of PLCE1 were associated with the prognosis of ESCC patients in a high-incidence region of northern China. The PLCE1 rs2274223 A/G and rs11599672T/G single-nucleotide polymorphisms (SNPs) were genotyped by polymerase chain reaction-ligase detection reaction method in 207 ESCC patients with survival information. The mean age ± standard deviation of the 207 ESCC patients was 60.3±7.9 years. Sex, age, smoking status and family history of upper gastrointestinal cancer were not found to be associated with the survival time of ESCC patients. The mean survival time of rs2274223

Association between polymorphisms of ABCB1 and prognosis in esophageal squamous cell carcinoma patients treated with taxane

“…Single nucleotide polymorphisms (SNPs), as a common form of germline variations, have been identified to be related to cancer development, progression and outcome. However, because of ethnicity differences and inadequate functional research, limited studies on the relationship between SNPs and ESCC survival have reached concordant conclusions 7–12 …”

“…However, because of ethnicity differences and inadequate functional research, limited studies on the relationship between SNPs and ESCC survival have reached concordant conclusions. [7][8][9][10][11][12] In the present study, genes from the taxane pharmacokinetics pathway were selected for determining SNPs because the taxane family was the most commonly used chemotherapy agent in Chinese ESCC patients. [13][14][15] Specifically, four genes from the ATP-binding cassette (ABC) superfamily, including ABCB1, ABCG2, ABCC1 and ABCC2, were chosen for further research.…”

Influencing factors of postoperative early delayed gastric emptying after minimally invasive Ivor-Lewis esophagectomy

“…Meanwhile, due to the use of thoracic laparoscopy in the process of lymph node dissection, the exposure of related nerves is reduced, and the postoperative complications are reduced[10,11]. However, patients treated by MIILE have a high incidence of early delayed gastric emptying (DGE)[12]. Postoperative DGE not only prolongs hospital stay and recovery time, but also increases the incidence of aspiration pneumonia[13,14].…”