2010
DOI: 10.1158/1535-7163.mct-09-0904
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Abstract: Peroxiredoxins (PRDX) are a family of thiol-dependent peroxidases. Among the six mammalian members of this family, PRDX6 is the only protein that additionally exhibits phospholipase A 2 (PLA 2 ) activity. The physiologic role of this interesting PRDX6 feature is largely unknown at present. In this study, we show that PRDX6 increases the metastatic potential of lung cancer cells. Functional analyses of the enzymatic activities of PRDX6, using specific pharmacologic inhibitors and mutagenesis studies, reveal tha… Show more

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Cited by 76 publications
(79 citation statements)
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“…According to recent studies by Chang and co-workers, PRDX6 has a high concentration in the metastatic breast and lung cancer cell, confirming the functional role of this enzyme to promote cellular invasiveness and metastatic potential in these cancer cells [Chang et al, 2007;Ho et al, 2010]. In addition, abnormal expression of PRDX6 associated with malignant transformation in oligodendroglioma suggests that PRDX6 may be considered a putative molecular predictive factor [Park et al, 2008].…”
Section: Discussionmentioning
confidence: 86%
“…According to recent studies by Chang and co-workers, PRDX6 has a high concentration in the metastatic breast and lung cancer cell, confirming the functional role of this enzyme to promote cellular invasiveness and metastatic potential in these cancer cells [Chang et al, 2007;Ho et al, 2010]. In addition, abnormal expression of PRDX6 associated with malignant transformation in oligodendroglioma suggests that PRDX6 may be considered a putative molecular predictive factor [Park et al, 2008].…”
Section: Discussionmentioning
confidence: 86%
“…Peroxiredoxins are a group of six proteins most noted for their antioxidant activity (34) but are also involved in signal transduction (35,36). Their actions have not only been implicated in neurodegenerative diseases but also as a target for cancer treatment and immune functioning (37)(38)(39)(40).…”
Section: Discussionmentioning
confidence: 99%
“…Elevated expression levels for Prdx6 have been demonstrated in association with a broad variety of human cancers including lymphoma and cancer of the breast, esophagus, lung, liver, ovaries, pancreas, bladder, thyroid, gingiva, tongue, skin, and mesothelium among others (121)(122)(123)(124)(125)(126)(127)(128)(129)(130)(131)(132)(133).…”
Section: Cancer and Carcinogenesismentioning
confidence: 99%