2011
DOI: 10.1523/jneurosci.4477-10.2011
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Abstract: The possibility of changing the number of synapses may be an important asset in the treatment of neurological diseases. In this context, the synaptogenic role of the phosphoinositide-3-kinase (PI3K) signaling cascade has been previously demonstrated in Drosophila. This study shows that treatment with a PI3K-activating transduction peptide is able to promote synaptogenesis and spinogenesis in primary cultures of rat hippocampal neurons, as well as in CA1 hippocampal neurons in vivo. In culture, the peptide incr… Show more

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Cited by 120 publications
(136 citation statements)
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“…One correlate of the activation of these pathways is increased synaptogenesis and levels of synaptic PSD95 (27,56). These results are consistent with previous findings of reduced PSD95 transcription and protein expression as well as fewer excitatory synapses and spines in Mecp2 mutant mice (5,11,57,58).…”
Section: Discussionsupporting
confidence: 92%
“…One correlate of the activation of these pathways is increased synaptogenesis and levels of synaptic PSD95 (27,56). These results are consistent with previous findings of reduced PSD95 transcription and protein expression as well as fewer excitatory synapses and spines in Mecp2 mutant mice (5,11,57,58).…”
Section: Discussionsupporting
confidence: 92%
“…The mechanisms through which BDNF influences spine growth are as yet unclear, but could be linked to a regulation of protein synthesis. Thus, PI3K, which interacts with AKT and has functional links with mTOR signalling, also regulates spinogenesis 50 . Furthermore, protein synthesis, mTOR signalling and spine turnover are affected in fragile X mental retardation protein (FMRP) knockout mice, a mouse model of fragile X syndrome 51 .…”
Section: Memory Consolidationmentioning
confidence: 99%
“…Genetic manipulations of NRG1/ERBB4 signaling in animal models lead to abnormal GABA neural circuit development and plasticity (11)(12)(13) and cause behavior alterations associated with attention and cognitive deficits, such as prepulse inhibition (PPI) deficits, working memory impairment, and hyperactivity (11,13). PI3K function has also been linked to neural circuit development, synaptic plasticity, and cognitive function (14,15).…”
mentioning
confidence: 99%
“…PI3K signaling has been shown to be involved in neural circuit development and synaptic plasticity (14,20). Because of this, one would intuitively expect that inhibition of PI3K signaling would result in decreased cognitive performance.…”
mentioning
confidence: 99%
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