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Cited by 7 publications
(11 citation statements)
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References 8 publications
(8 reference statements)
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“…7 A reported increased risk of cardiovascular events in patients taking clopidogrel plus a proton pump inhibitor from observational data, for example, was not sustained by subsequent analyses of randomized trials, even though there was a plausible biological mechanism. 8,9 Indeed, trial data found that proton pump inhibitor use in this patient population decreased the risk of gastrointestinal events without a detectable increase in cardiovascular risk; thus, avoidance of proton pump inhibitors in this setting was actually associated with overall clinical harm. Residual confounding likely plays some role in these disparate results and, [10][11][12] unfortunately, "positive" findings from small, early studies are also often more memorable (and more often repeated) than later "negative" findings from larger, more definitive evaluations.…”
Section: Conflicts Of Interestmentioning
confidence: 97%
See 2 more Smart Citations
“…7 A reported increased risk of cardiovascular events in patients taking clopidogrel plus a proton pump inhibitor from observational data, for example, was not sustained by subsequent analyses of randomized trials, even though there was a plausible biological mechanism. 8,9 Indeed, trial data found that proton pump inhibitor use in this patient population decreased the risk of gastrointestinal events without a detectable increase in cardiovascular risk; thus, avoidance of proton pump inhibitors in this setting was actually associated with overall clinical harm. Residual confounding likely plays some role in these disparate results and, [10][11][12] unfortunately, "positive" findings from small, early studies are also often more memorable (and more often repeated) than later "negative" findings from larger, more definitive evaluations.…”
Section: Conflicts Of Interestmentioning
confidence: 97%
“…Additional corroborating evidence includes the finding that patients with CRC in the Cancer Genome Atlas that harbor mutations associated with reduced PDE5 expression had longer survival. 7 Finally, experimental studies have shown that PDE5 inhibitors have anticancer activity in vitro 3,8 and in vivo in both inflammation-related 9-11 and inflammation-independent 12 cancer animal models.…”
mentioning
confidence: 99%
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“…Accelerated turnover of the intestinal epithelium shows a decrease in cGMP, which favors susceptibility to tumorigenesis. PDE5 inhibitors suppress intestinal carcinogenesis and improve epithelial barrier function, inhibiting cGPM degradation and raising its levels (76). It has been proven that sildenafil combined with curcumin increases the efficacy of 5-Fluorouracil (antineoplastic drug) in controlling CT26 colorectal tumors.…”
Section: Colorectal Cancermentioning
confidence: 99%
“…In addition, it was recently reported that treatment with the PDE5 inhibitor sildenafil can inhibit carcinogenesis in two different models of colon cancer in mice (Islam et al, 2017;Sharman et al, 2018). In contrast to in vitro studies with colon cancer cell lines, the in vivo inhibition of carcinogenesis was shown to result from suppression of polyp initiation, and that sildenafil treatment did not affect the growth of existing tumors (Islam and Browning, 2018). The present study has tested the idea that treatment of colon cancer cells with PDE inhibitors in vitro can inhibit growth by increasing cGMP and activating PKG signaling.…”
Section: Introductionmentioning
confidence: 99%