Phosphodiesterase-5 Inhibitors and Dementia Risk: Confounding by Indication in Real-World Studies
Che-Yuan Wu,
Walter Swardfager
Abstract:Pharmacoepidemiologic studies using routinely collected data allow researchers to propose drugs for repurposing trials for dementia prevention or treatment. A recent cohort study reported a 54% lower dementia risk among users of sildenafil compared to users of certain cardiovascular medications. We caution that “confounding by indication” can arise when outcomes are compared between a drug of interest and an inappropriate comparator. Here, we emphasize important considerations in selecting an active comparator… Show more
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