Phosphodiesterase-5 Inhibitors and Dementia Risk: A Real-World Study
Naomi Gronich,
Nili Stein,
Walid Saliba
Abstract:<b><i>Introduction:</i></b> Biological and scarce epidemiological evidence suggested that phosphodiesterase-5 inhibitors (PDE5i) might reduce dementia risk. We aimed to examine the association between PDE5i and dementia using real-world data. <b><i>Methods:</i></b> Two retrospective cohorts within the database of Clalit, the largest healthcare provider in Israel (2005–2023), were studied. The first cohort included new daily users, older than 50 years of age, of l… Show more
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