2018
DOI: 10.18632/aging.101559
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Abstract: Rolipram is a selective phosphodiesterase 4 (PDE4) inhibitor that exerts a variety of effects, including anti-inflammatory, immunosuppressive, and anti-tumor effects. The aim of this study was to investigate the effect of rolipram on metabolic disorder and its underlying mechanisms. Metabolic disorder was induced in 8-week-old wild type BABL/c mice by administration of D-galactose for 4 weeks. Simultaneously the mice were administered vehicle or rolipram. Alternatively, beginning at 3 or 21 months, the mice we… Show more

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Cited by 12 publications
(10 citation statements)
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References 39 publications
(42 reference statements)
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“…PDE4 inhibitors have been proved to have many functions as follows: 1) reverse the memory impairment caused by β-amyloid peptide through weakening the inflammation and apoptosis of neurons; improve memory loss and cognitive function in patients with Alzheimer's disease 70 , 71 ; 2) inhibit rheumatoid arthritis by reducing the tumor necrosis factor α (TNF-α) produced by human synovial cells 72 ; 3) treat airway inflammation, such as asthma and chronic obstructive pulmonary diseases through inhibiting the release of TNF-α by human peripheral blood mononuclear cells, the proliferation of lymphocytes and the production of cytokines 73 ; 4) treat metabolic diseases related to aging 74 , 75 ; 5) treat alcoholic fatty liver disease and nonalcoholic fatty liver disease 75 - 77 and so on. In addition, zardaverine, a double selective PDE3/4 inhibitor, can induce cell cycle arrest in G0/G1 phase of HCC cells by regulating cyclin 78 .…”
Section: Resultsmentioning
confidence: 99%
“…PDE4 inhibitors have been proved to have many functions as follows: 1) reverse the memory impairment caused by β-amyloid peptide through weakening the inflammation and apoptosis of neurons; improve memory loss and cognitive function in patients with Alzheimer's disease 70 , 71 ; 2) inhibit rheumatoid arthritis by reducing the tumor necrosis factor α (TNF-α) produced by human synovial cells 72 ; 3) treat airway inflammation, such as asthma and chronic obstructive pulmonary diseases through inhibiting the release of TNF-α by human peripheral blood mononuclear cells, the proliferation of lymphocytes and the production of cytokines 73 ; 4) treat metabolic diseases related to aging 74 , 75 ; 5) treat alcoholic fatty liver disease and nonalcoholic fatty liver disease 75 - 77 and so on. In addition, zardaverine, a double selective PDE3/4 inhibitor, can induce cell cycle arrest in G0/G1 phase of HCC cells by regulating cyclin 78 .…”
Section: Resultsmentioning
confidence: 99%
“…Furthermore, AMPK helps to enhance utilization of glucose by skeletal muscles and ameliorates insulin sensitivity [ 42 , 43 ], inhibits adipose regeneration, and fortifies lipolysis and lipid burning of adipose cells [ 44 , 45 ]. Wang et al [ 46 ] had indicated that the phosphodiesterase 4 inhibitor (PDE4), rolipram, can promote AMPK phosphorylation and upregulate the expression level of SIRT6 in the liver and kidney of aging mice. This had a positive effect on lipid metabolism by inhibiting adipose deposition associated with senescence, through increasing the concentration of intracellular cyclic adenosine monophosphate (cAMP).…”
Section: Discussionmentioning
confidence: 99%
“…SIRT6 has been also shown to be downregulated in obese rats, but it is upregulated after energy restriction-induced weight loss, together with an increase of oxidative stress markers [ 386 ]. The drug rolipram, which reduces ageing-related adipose disposition, was shown to increase SIRT6 levels in livers of mice [ 387 ]. Moreover, the drug T1AM increases SIRT6 levels, whereas it decreases SIRT4 levels, as well as reversing obesity through metabolic reprogramming [ 378 ].…”
Section: The Role Of Sirtuins In Metabolic Tissuesmentioning
confidence: 99%