Phosphine Oxide Polymer for Water-Soluble Nanoparticles

Abstract

A phosphine oxide polymer was developed using bis(dichlorophosphino)ethane and poly(ethylene glycol). This polymer system was used to transfer various nanoparticles from organic solvents to water, retaining their physical properties and reactivities.

A High‐Performance Magnetic Resonance Imaging T2 Contrast Agent

“…[16,17] For biomedical applications, it is indispensable to transfer these nanoparticles to an aqueous phase. Several studies have dealt with a variety of methodological improvements including ligand exchange with tetramethylammonium hydroxide (TMAOH), [18] dimercaptosuccinic acid (DMSA), [19] phosphine oxide polymers, [20] and dendrons [21] to enhance stability of nanoparticles in aqueous solution. Alternatively, a layer of amphiphilic molecules such as poly(maleic anhydride-alt-1-tetradecene), [22] surfactant/lipid, [23] and a-cyclodextrin [24] have been used to form an intercalating structure with the hydrophobic capping molecules on the particle surface.…”

Quantum dots, lighting up the research and development of nanomedicine

“…One of the easiest ways is the attachment of thiolated poly(ethylene glycol) polymers, which renders the water solubility and reduced unspecific cellular uptake of QDs. [9][10][11][12] Other polymers with varying chain lengths and number of binding dentates, such as PEGylated dihydrolipoic acid, [13][14][15] dendrimers, 16,17 and multidentate phosphine polymers, 18 are also used to stabilize QDs in aqueous solution. An alternative protocol for a solubilization and stabilization is ligand capping by various amphiphilic polymers such as poly(maleic anhydride alt-1-tetradecene), 19 triblock copolymer, 5 and alkyl-modified poly (acrylic acid) [20][21][22] to form highly stable polymer linking or micelle-like structures.…”

Synthesis, Characterization and Evaluation of the Cytotoxicity of Ni‐Doped Zn(Se,S) Quantum Dots

“…Therefore, the substitution of Zn 2+ atoms by Ni 2+ atoms in the lattice is possible. Frequently, QDs are synthesized in organic phase under refluxing, using coordinating solvents like trioctylphosphine oxide (TOPO), trioctylphosphine (TOP), and hexadecylamine [14][15][16][17][18][19][20]. Although, the reflux technique is highly reproducible and able to produce nanocrystals of narrow size distribution; the long time period required for the synthesis; the limited temperatures that can be achieved by this technique; and the generation of QDs stable in organic media limit its application.…”

“…The possibility to produce water-stable nanoparticles using thiols agents under microwave irradiation is desirable to biomedical applications [19][20][21][22][23][24]. In this study, we have produced water-stable Nidoped Zn(Se,S) nanocrystals of high-optical quality using 3-mercaptopropionic acid (MPA) under microwave irradiation.…”