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“…For example, specificities of individual antibodies to phosphatidylinositol phosphate were identified that either did or did not crossreact with phosphatidylinositol or phosphatidylinositol bisphosphate (28). Monoclonal antibodies to cardiolipin can react with cardiolipin or even phosphatidylethanolamine in the hexagonal HI, phase, but not with the lipids in the bilayer configuration (29).…”
Section: Discussionmentioning
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“…For example, specificities of individual antibodies to phosphatidylinositol phosphate were identified that either did or did not crossreact with phosphatidylinositol or phosphatidylinositol bisphosphate (28). Monoclonal antibodies to cardiolipin can react with cardiolipin or even phosphatidylethanolamine in the hexagonal HI, phase, but not with the lipids in the bilayer configuration (29).…”
Section: Discussionmentioning
“…Specific polyclonal and monoclonal antibodies to phosphatidylinositol-4-phosphate (PIP) can be readily induced in mice by injection of liposomes containing PIP as an antigen and lipid A as an adjuvant (3,33). Four complement-fixing murine MAbs to PIP, selected for their abilities to react with liposomes containing PIP but not with liposomes lacking PIP, have been extensively studied (2,3,6,16,17,30,32,33).…”
mentioning
“…Four complement-fixing murine MAbs to PIP, selected for their abilities to react with liposomes containing PIP but not with liposomes lacking PIP, have been extensively studied (2,3,6,16,17,30,32,33). The anti-PIP antibodies are characterized by the ability to react with various types of phosphorylated molecules, including certain closely related anionic phospholipids that have charged nonzwitterionic phosphate groups, such as CL (2), and also with denatured DNA (30).…”
mentioning
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