Phomopsinones A–D: Four New Pyrenocines from Endophytic Fungus Phomopsis sp.

Abstract

The structural elucidation of the compounds isolated from the endophytic Phomopsis sp. revealed phomopsinones A-D (1-4), four new α-pyrone derivatives. Three known compounds were also isolated, namely two phomosines, phomosine A (5) and phomosine C (6), and ergosterol (7). The structures of these compounds were determined by spectroscopic analysis ( 1H, 13C, 1H- 1H COSY, HMQC, HMBC, and ROESY NMR, and mass spectrometry), supported by molecular modeling. The absolute configurations of the new compounds 1-4 were determined by circular dichroism spectroscopy and TDDFT calculations. Preliminary studies indicated that compounds 1 and 4 show strong and good antifungal activity, respectively. Similarly, compounds 2 and 3 showed good antifungal and moderate antibacterial activities as well as antialgal activities

Coniothyren: a new phenoxyphenyl ether from the endophytic fungus,Coniothyriumsp.

“…Endophytes, commonly present in almost all plants, are being recognized as a potential source of useful medicinal compounds [1]. Continuing our work on the characterization of structurally novel and/or biologically active metabolites isolated from fungal endophyte cultures [1][2][3][4][5][6][7][8][9][10], we investigated the endophytic fungus Coniothyrium sp., consisting of Fucus sp. that resulted in the isolation and structural determination of one new phenoxyphenyl ether, named coniothyren (1), together with two known compounds, coniol (2) and (þ)-epoxydon (3).…”

Antimicrobial activity of two mellein derivatives isolated from an endophytic fungus

“…It has been reported that endophytic fungi have in the past provided a number of novel and interesting organic compounds that showed quite notable biological activities and a high degree of biodiversity (Hussain et al, 2009a;2012;Saleem et al, 2011). Moreover, fungal natural products have also played a crucial role in producing a number of lead compounds for new drug candidates (Hussain et al, 2009a, b;2012).…”

“…Moreover, fungal natural products have also played a crucial role in producing a number of lead compounds for new drug candidates (Hussain et al, 2009a, b;2012).…”

Endophytic Fungi as a Source of Novel Metabolites

“…Santolina chamaecyparissus Antifungal activity, antibacterial, and algicidal activities [111] Phomopsinone D (18) Phomopsis sp.…”