Pheochromocytoma in a Patient With End-Stage Renal Disease

Godfrey, John A.; Rickman, Otis B.; Williams, Amy W.; Thompson, Geoffrey B.; Young, William F.

doi:10.1016/s0025-6196(11)62118-6

Cited by 27 publications

(10 citation statements)

References 25 publications

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“…Treatment of pheochromocytoma in patients with ESRD follows the same principles as that for patients with normal renal function (27). Most pheochromocytomas are benign and can be excised totally.…”

Section: Discussionmentioning

confidence: 99%

“…The high levels of CA generally reduce the circulating blood volume, and a true hypotensive shock can occur from sudden vasodilation after tumor ablation. Careful preoperative preparation, most often consisting of partial CA blockade a nd volume expansion, has been shown to be useful (27). In patients with ESRD, symptoms such as headache, palpitations, hypertension, and fluctuations of blood pressure are common.…”

Section: Discussionmentioning

confidence: 99%

“…Once the tumor is suspected, diagnosis is relatively straightforward. Diagnosing these tumors is important because they are a curable cause of hypertension, although 10% are malignant, and paroxysm can be associated with severe morbidity and mortality (27). It is well known that there is a high incidence of renal cell carcinoma in patients with ESRD on HD (32), and abdominal CT scanning and ultrasonography are now conducted routinely.…”

Section: Discussionmentioning

confidence: 99%

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Four Cases of Pheochromocytoma in Patients with End-stage Renal Disease

Saeki

Suzuki²,

Yamazaki

et al. 2003

Intern. Med.

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Although pheochromocytoma in a patient with endstage renal disease (ESRD)is considered extremely rare, we recently encountered 4 ESRD patients with pheochromocytoma. Three were symptomatic, and in the fourth patient the tumor was discovered as an adrenal incidentaloma. Plasma catecholamine levels were significantly increased in two patients. In each case, 131I-MIBG scintigraphy showedaccumulation of the radionuclide in the adrenal tumor, which was identified by MRIor CT scanning, and adrenalectomy was conducted without serious complications. Although paroxysmal hypertension is a commonsymptom in patients with ESRD, pheochromocytoma must be eliminated by careful evaluation.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Four Cases of Pheochromocytoma in Patients with End-stage Renal Disease

Saeki

Suzuki²,

Yamazaki

et al. 2003

Intern. Med.

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“…The renal handling of catecholamines is complex and, in patients with renal insu¤-ciency or renal failure, plasma catecholamines or metadrenalines can be increased 2-or 3-fold above the upper reference limits in non-phaeochromocytoma patients. 174 Drugs can also have a signi¢cant in£uence on catecholamine concentrations in both urine and plasma. Not only can medications such as labetalol or amethyldopa interfere with many methods, 171^173 but drugs can induce increased or decreased levels of catecholamines and metabolites through their pharmacological mode of action.…”

Section: Factors In Uencing Catecholamine Excretionmentioning

confidence: 99%

Measurement of catecholamines and their metabolites

2004

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Analysis of the low levels of catecholamines and metabolites in tissue and biological uids has necessitated the use of highly sensitive analytical techniques. Earlier procedures utilizing radioenzymatic and immunological assays, gas chromatography or uorimetry have generally been superseded by highly sensitive and selective chromatographic methods utilizing electrochemical or uorimetric detection. The development of high-performance liquid chromatography (HPLC) methods for the measurement of plasma metadrenalines and the combination of HPLC with tandem mass spectrometry provides additional procedures with minimum interference from drugs and drug metabolites. This review summarizes the methodology currently available for the measurement of catecholamines and metabolites in plasma and urine, the in uence of sample collection protocols and the clinical application of the methods for the biochemical detection of catecholamine-secreting tumours.

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“…To our knowledge, 18 cases of pheochromocytoma in association with ESRD have been reported in the English literature (Table 2), [3][4][5][6][7][8][9][10][11][12][13][14][15][16] and resection was performed successfully in all cases. The patients involved were 10 men and eight women, aged 25-59 years (mean age 42.8 years).…”

Section: Discussionmentioning

confidence: 99%

Successful treatment of pheochromocytoma in a patient with hemodialysis: a case report and review of the literature

et al. 2013

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Pheochromocytoma in a patient with end-stage renal disease is considered rare. A 40-year-old man who had undergone renal transplantation in childhood and had been on hemodialysis (HD) for the last 6 years suddenly developed paroxysmal palpitations and hypertension. His plasma catecholamine (CA) level was increased and a right adrenal mass was found on magnetic resonance imaging. He was diagnosed with pheochromocytoma, and right adrenalectomy was conducted after pretreatment with CA blockade and volume expansion. The surgery was conducted safely, his symptoms resolved, and his plasma CA level decreased to the normal range. Since paroxysmal hypertension is a common symptom in patients with HD, careful attention is needed to diagnose pheochromocytoma.

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Pheochromocytoma in a Patient With End-Stage Renal Disease

Cited by 27 publications

References 25 publications

Four Cases of Pheochromocytoma in Patients with End-stage Renal Disease

Four Cases of Pheochromocytoma in Patients with End-stage Renal Disease

Measurement of catecholamines and their metabolites

Successful treatment of pheochromocytoma in a patient with hemodialysis: a case report and review of the literature

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