Phenylketonuria

Phenylketonuria: a review

“…Clinical impressions in other centres also suggest that children who are already brain-damaged to some degree may benefit from long-term dietary modifications if not strict dietary restrictions (Langdell, 1965). Such children in this clinic are kept on a largely vegetarian diet with protein supplied in the form of a low phenylalanine milk.…”

Intellectual Development and Academic Achievement of Children Treated Early for Phenylketonuria

“…The majority of reports indicated that late treatment generally did not appreciably increase IQ. Benefits of treatment of older children who were already mentally impaired were usually limited to improvement in associated neurological disturbances, although further deterioration was arrested (Langdell 1965, Sutherland et al 1966, Baumeister 1967, Birch and Tizard 1967, Hsia 1967).…”