Phenylethanoids from the Flowers of Rosa rugosa and Their Biological Activities

Shu, Li‐Dan; Liu, Yang; Shen, Yanqiong; Zhang, Yingjie; Hu, Qiu‐Fen

doi:10.5012/bkcs.2013.34.1.246

Cited by 17 publications

(5 citation statements)

References 10 publications

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“…Artun et al [30] recently reported that methanolic extract of R. damascena exhibits selective cytotoxic effects on human cervix cancer (HeLa) cells compared to normal kidney epithelial (Vero) cells. Additionally, not only the extracts of Rosa species but also various compounds isolated from Rosa species (such as bee pollen polysaccharides, phenylethanoids, and essential oils) have been reported to exhibit cytotoxic effects in colon, leukemia, liver, breast and oropharyngeal epidermoid carcinoma cell lines [13], [31], [32].…”

Section: Discussionmentioning

confidence: 99%

Cytotoxic effect of Rosa canina extract on human colon cancer cells through repression of telomerase expression

Turan

Demir

Kilinç

et al. 2018

Journal of Pharmaceutical Analysis

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Rosa canina is a member of the genus Rosa that has long been used for medical objectives. Several studies have reported cytotoxic effects of different Rosa species, but there has been only limited investigation of the cytotoxic effect of R. canina. The purpose of the current study was to examine the potential effect of R. canina extract on cell viability, the cell cycle, apoptosis, and the expression of telomerase in human colon cancer (WiDr) cells. The cytotoxic effect of the extract was determined using MTT assay. The mechanism involved in the cytotoxic effect of the extract was then evaluated in terms of apoptosis and the cell cycle using flow cytometry. Mitochondrial membrane potential (MMP) was investigated using the fluorometric method, and expression levels of telomerase were studied using RT-PCR. R. canina extract exhibited a selective cytotoxic effect on WiDr cells compared with normal colon cells. The extract induced cell cycle arrest at the S phase and apoptosis via reduced MMP in WiDr cells. R. canina extract significantly repressed telomerase expressions at treatment times of 48 and 72 h in WiDr cells. Our results suggest that R. canina may have considerable potential for development as a novel natural product-based anticancer agent.

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Section: Discussionmentioning

confidence: 99%

Cytotoxic effect of Rosa canina extract on human colon cancer cells through repression of telomerase expression

Turan

Demir

Kilinç

et al. 2018

Journal of Pharmaceutical Analysis

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“…20 The constituents of Roase Rugosae Flos include polyphenols, flavonoids, essential oils, polysaccharides, pigments and vitamins. [48][49][50][51][52] Among them, quercetin and kaempferol have antidepressant activities and thus may be the main antidepressant constituents of the drug. The water extracts (drugs : water = 1 kg : 10 L) of Roase Rugosae Flos (1 g/kg b.w) were reported to prevent exercise-induced stress in experimental mice models.…”

Section: Roase Rugosae Flosmentioning

confidence: 99%

Chinese Pharmacopoeia Revisited: A Review of Anti-Depression Herbal Sources

Gao

Yang

et al. 2021

Natural Product Communications

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Depression, which can be accompanied by many fatal diseases and a low life quality, has become the leading cause of ill health and disability worldwide. However, Chinese Pharmacopoeia, the most authoritative and evidence-based encyclopedia of Traditional Chinese Medicine (TCM), could contain leads and insights into the development of new antidepressant drugs. In this work, nine herbal medicines with ‘dispel melancholy functions’ specifically documented in Chinese Pharmacopoeia have been comprehensively reviewed with respect to clinical trials, and phytochemical and pharmacological aspects. The nine drugs are Rosae Chinensis Flos, Croci Stigma, Albiziae Cortex and Flos, Roase Rugosae Flos, Curcumae Radix, Hyperici Perforati Herba, Cyperi Rhizoma and Bupleuri Radix. The mechanisms of action of their functional antidepressant compounds, including gallic acid, hypericin, kaempferol, crocetin, crocin, quercetin, luteolin, isorhamnetin, curcumin, hyperforin, adhyperforin, catechin, rutin, puerarin, and saikosaponins A and D, have been collected and discussed. These traditional Chinese herbs and their active compounds provide a promising resource to develop effective new antidepressant drugs in future. Moreover, mechanistic investigations, safety verification and large-scale clinical trials are still expected to finally transform such TCM-based antidepressant resources to new drugs for patients suffering from depression.

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“…Acyloins (also known as α-hydroxy ketones) are widely found as structural motif in natural products [1][2][3][4][5][6][7] and bioactive molecules [8][9][10][11] (Figure 1). They can also be used as building blocks in organic synthesis [12][13][14], involved in numerous transformations to other important functional groups such as dicarbonyls [15], diols [16], amino ketones [17] and so on.…”

Section: Introductionmentioning

confidence: 99%

Visible-light-induced nickel-catalyzed α-hydroxytrifluoroethylation of alkyl carboxylic acids: Access to trifluoromethyl alkyl acyloins

Chen,

Xu,

Chen

et al. 2023

Beilstein J. Org. Chem.

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A visible-light-induced nickel-catalyzed cross coupling of alkyl carboxylic acids with N-trifluoroethoxyphthalimide is described. Under purple light irradiation, an α-hydroxytrifluoroethyl radical generated from a photoactive electron donor–acceptor complex between Hantzsch ester and N-trifluoroethoxyphthalimide was subsequently engaged in a nickel-catalyzed coupling reaction with in situ-activated alkyl carboxylic acids. This convenient protocol does not require photocatalysts and metal reductants, providing a straightforward and efficient access to trifluoromethyl alkyl acyloins in good yields with broad substrate compatibility. The complex bioactive molecules were also compatible with this catalytic system to afford the corresponding products.

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Phenylethanoids from the Flowers of Rosa rugosa and Their Biological Activities

Cited by 17 publications

References 10 publications

Cytotoxic effect of Rosa canina extract on human colon cancer cells through repression of telomerase expression

Cytotoxic effect of Rosa canina extract on human colon cancer cells through repression of telomerase expression

Chinese Pharmacopoeia Revisited: A Review of Anti-Depression Herbal Sources

Visible-light-induced nickel-catalyzed α-hydroxytrifluoroethylation of alkyl carboxylic acids: Access to trifluoromethyl alkyl acyloins

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