Phenylethanoid glycosides from the stems of Callicarpa peii (hemostatic drug)

Wu, Aizhi; Zhai, Ya-Jing; Zhao, Zhongxiang; Zhang, Cui‐Xian; Chen, Lin; Chang, Zhu

doi:10.1016/j.fitote.2012.12.014

Cited by 25 publications

(8 citation statements)

References 8 publications

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“…A literature survey revealed that PGs were responsible for the bioactivities in many medical studies . Although the benefits of PGs were obvious, some reported disposition properties in vivo indicated that there were inevitable complicated factors facing PGs development and applications.…”

Section: Introductionmentioning

confidence: 99%

Simultaneous determination of savaside A, acteoside, and isoacteoside in rat plasma by UHPLC–MS/MS: Comparative pharmacokinetic and bioavailability characteristics of Monochasma savatieri via different routes of administration

Feng

Song

et al. 2018

J of Separation Science

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Phenylethanoid glycosides are the bioactive components in Monochasma savatieri that primarily contains savaside A, acteoside, and isoacteoside. Pharmacological research has been comprehensive, but there have been few studies on pharmacokinetics, especially about savaside A. An ultra high performance liquid chromatography with tandem mass spectrometry with multiple reaction monitoring mode was developed and validated for the simultaneous determination of the three compounds from M. savatieri. Meanwhile, this method was fully validated and successfully applied to compare the pharmacokinetics and bioavailability following four different routes included intravenous injection, intraperitoneal injection, muscle injection, and oral administration. The results indicated that the three compounds could be rapidly absorbed within 1 h, and the main pharmacokinetic parameters showed significant differences (P < 0.05). The bioavailability of oral administration, intramuscular injection, and intraperitoneal injection did not exceed 0.2, 25, and 10%, respectively. Comparing the bioavailability, it exhibited that acteoside > isoacteoside > savaside A following the four administration routes. Notably, the isomerization position of acteoside and isoacteoside mainly occurred in the liver according to the pharmacokinetics profiles of intraperitoneal and intravenous injection, in addition, isoacteoside exhibited more structural selectivity than acteoside in vivo. It demonstrated that three compounds undergo different processes, mainly affected by the first‐pass effect and their intestinal stability is extremely poor.

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Section: Introductionmentioning

confidence: 99%

Simultaneous determination of savaside A, acteoside, and isoacteoside in rat plasma by UHPLC–MS/MS: Comparative pharmacokinetic and bioavailability characteristics of Monochasma savatieri via different routes of administration

Feng

Song

et al. 2018

J of Separation Science

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“…A crude extract of the leaves and twigs of C. bodinieri was chromatographed over a silica gel column and eluted with a CHCl 3 −acetone gradient solvent system (1:0−0:1). The resulting fractions were separated by repeated column chromatography and preparative HPLC to afford nine new abietane-type diterpenoids (1−9, bodinieric acids A−I) and six known compounds, which were identified as 13-hydroxy-8,11,13-podocatpatrien-18-oic acid 22 (10), 18-oxoferruginol 23 (11), 15-hydroxydehydroabietic acid 24 (12), dehydroabietic acid 25 (13), dehydroabietinol 26 (14), and taxodascen C 27 (15).…”

Section: ■ Results and Discussionmentioning

confidence: 99%

“…Callicarpa bodinieri is one of the species in the genus Callicarpa that has been used widely in traditional medicine, for the treatment of inflammation, rheumatism, analgesia, hematemesis, gastrointestinal bleeding, scrofula, and swollen sores . The diverse therapeutic applications of plants in the genus Callicarpa may be attributed to their bioactive constituents, including terpenoids, lignans, glycosides, − flavonoids, phenolic acids, − and their volatile oils. , The diterpenoids isolated from this genus have been reported to have anti-inflammatory activities in different disease models; − however, their target has not been identified.…”

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confidence: 99%

Isolation, Characterization, and Structure–Activity Relationship Analysis of Abietane Diterpenoids fromCallicarpa bodinierias Spleen Tyrosine Kinase Inhibitors

et al. 2018

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Species belonging to the genus Callicarpa are used traditionally in Chinese medicine for the treatment of inflammation, rheumatism, and pain. Investigation of the leaves and twigs of Callicarpa bodinieri resulted in the isolation of nine new abietane diterpenoids, bodinieric acids A-I (1-9), along with six known compounds (10-15). The structures of 1-9 were elucidated on the basis of the interpretation of their HRESIMS and NMR data and by ECD calculations. To explore the potential therapeutic target of this plant for immune-mediated disease, the inhibitory activities of the isolates obtained were determined against 13 kinase enzymes. Eight compounds exhibited moderate inhibitory effects on spleen tyrosine kinase (SYK), and the IC values of compounds 2 and 6 were 7.2 and 10.7 μM, respectively. In addition, a preliminary structure-activity relationship of this scaffold was analyzed with both molecular docking and a 3D-QSAR pharmacophore model.

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“…Because the phytochemical profile of the Taiwanese endemic plant Callicarpa hypoleucophylla has never been analyzed, we carried out an investigation of the constituents and bioactivity of C. hypoleucophylla. A meticulous separation of an ethanolic extract of C. hypoleucophylla led to the isolation of two new clerodane-type diterpenoids that we named callihypolins A and B (1 and 2), together with seven known analogues (3)(4)(5)(6)(7)(8)(9). The anti-inflammatory evaluation of these isolates is also presented in this paper.…”

Section: Introductionmentioning

confidence: 95%

“…The phytochemical investigation of this genus has resulted in the identification of diterpenoids, phenylethanoids, phenypropanoids, and flavonoids. These components display various biological effects, such as anti-inflammatory [4][5][6], anti-platelet aggregation [7], hemostatic [8], antioxidative [9][10], cytotoxic [6,[11][12], and neuroprotective [13], antitubercular [14], hepatoprotective [15][16], antimicrobial [17], anti-arthritic [18], as well as analgesic properties [19]. From the above-mentioned phytochemical and biological studies, we know this genus may offer a rich supply of bioactive phytochemicals.…”

Section: Introductionmentioning

confidence: 99%

Clerodane Diterpenoids from Callicarpa hypoleucophylla and Their Anti-Inflammatory Activity

Lin

Chen

et al. 2020

Molecules

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Plants of the genus Callicarpa are known to possess several medicinal effects. The constituents of the Taiwan endemic plant Callicarpa hypoleucophylla have never been studied. Therefore, C. hypoleucophylla was selected for our phytochemical investigation. Two new clerodane-type diterpenoids, named callihypolins A (1) and B (2), along with seven known compounds were isolated from the leaves and twigs of the Lamiaceae plant C. hypoleucophylla and then characterized. The structures of compounds 1 and 2 were elucidated by spectroscopic data analysis, specifically, two-dimension nuclear magnetic resonance (NMR). The anti-inflammatory activity of compounds 1–9 based on the suppression of superoxide anion generation and elastase release was evaluated. Among the isolates, compounds 2–4 showed anti-inflammatory activity (9.52−32.48% inhibition at the concentration 10 μm) by suppressing superoxide anion generation and elastase release. Our findings not only expand the description of the structural diversity of the compounds present in plants of the genus Callicarpa but also highlight the possibility of developing anti-inflammatory agents from Callicarpa endemic species.

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Phenylethanoid glycosides from the stems of Callicarpa peii (hemostatic drug)

Cited by 25 publications

References 8 publications

Simultaneous determination of savaside A, acteoside, and isoacteoside in rat plasma by UHPLC–MS/MS: Comparative pharmacokinetic and bioavailability characteristics of Monochasma savatieri via different routes of administration

Simultaneous determination of savaside A, acteoside, and isoacteoside in rat plasma by UHPLC–MS/MS: Comparative pharmacokinetic and bioavailability characteristics of Monochasma savatieri via different routes of administration

Isolation, Characterization, and Structure–Activity Relationship Analysis of Abietane Diterpenoids fromCallicarpa bodinierias Spleen Tyrosine Kinase Inhibitors

Clerodane Diterpenoids from Callicarpa hypoleucophylla and Their Anti-Inflammatory Activity

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