Phenylboronic Acid Grafted Chitosan as a Glucose-Sensitive Vehicle for Controlled Insulin Release

Wu, Zhongming; Zhang, Shaomin; Zhang, Xinge; Shu, Shujun; Chu, Tianci; Yu, Demin

doi:10.1002/jps.22463

Cited by 50 publications

(39 citation statements)

References 40 publications

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“…size and water solubility), are characterised by low toxicity and this was confirmed by in vitro (Wu Z et al, 2011) and in vivo (Konno, 2007) experiments. Although they have been criticised for non-specifically binding hydroxyl containing compounds, the concentration of such structures in the interstitial fluid of the subcutaneous space is substantially lower than the glucose concentration, (Huttunen, 1971;Ino et al, 2005;Ellmerer et al, 1998;Kawasaki and Yamanouchi, 2002) making boronates attractive agents for the purpose of this study.…”

Section: Introductionmentioning

confidence: 50%

A near infrared holographic glucose sensor

Vezouviou

Lowe

2015

Biosensors and Bioelectronics

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Section: Introductionmentioning

confidence: 50%

A near infrared holographic glucose sensor

Vezouviou

Lowe

2015

Biosensors and Bioelectronics

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“…In the present investigation, an EE% of 81% ± 1.2% was obtained. The PEC method has been used by several researchers to encapsulate insulin in chitosan nanoparticle [7,10,32]. Wu et al, formulated nanoparticles via PEC with an EE% ranging from 49%–59% and contend that this variability was attributed to the amount of insulin used and the molecular weight of the polymer [10].…”

Section: Resultsmentioning

confidence: 99%

“…As a result, it has been studied for potential use in various pharmaceutical dosage forms including beads, microparticles and nanoparticles [5,6,7]. Recently, various researchers have successfully introduced stimuli-responsive moieties such as concavalin A [8], glucose oxidase [9] and boronic acids [10] to chitosan with the aim to regulate the release of insulin from their delivery systems. This pursuit fits well with the quest for appropriate management of Type 1 diabetes, which necessitates repeated and life-long subcutaneous injections of insulin.…”

Section: Introductionmentioning

confidence: 99%

Cross-Linked Dependency of Boronic Acid-Conjugated Chitosan Nanoparticles by Diols for Sustained Insulin Release

et al. 2016

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Boronic acids have been widely investigated for their potential use as glucose sensors in glucose responsive polymeric insulin delivery systems. Interactions between cyclic diols and boronic acids, anchored to polymeric delivery systems, may result in swelling of the delivery system, releasing the drug. In this study, 4-formylphenylboronic acid conjugated chitosan was formulated into insulin containing nanoparticles via polyelectrolyte complexation. The nanoparticles had an average diameter of 140 ± 12.8 nm, polydispersity index of 0.17 ± 0.1, zeta potential of +19.1 ± 0.69 mV, encapsulation efficiency of 81% ± 1.2%, and an insulin loading capacity of 46% ± 1.8% w/w. Changes in size of the nanoparticles and release of insulin were type of sugar- and concentration-dependent. High concentration of diols resulted in a sustained release of insulin due to crosslink formation with boronic acid moieties within the nanoparticles. The formulation has potential to be developed into a self-regulated insulin delivery system for the treatment of diabetes.

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“…Drugs as the insulin mimetics which act directly on the insulin receiving cells rather than the insulin-producing cells have to be distributed in the endothelium of the complete body. If no specific organ is identified as target nanoparticulated preparation can provide a long-term release in order to reduce the administration frequency especially with a glucose-stimulation sensitive coating or polymer as it was described before for insulin delivery [63,64]. So far no nanoor microparticles using the combination of glucose sensing with insulin mimetic drugs are used as long-circulating self-activating drug vehicles.…”

Section: Discussionmentioning

confidence: 98%