Biochemical Pharmacology volume 77, issue 8, P1358-1363 2009 DOI: 10.1016/j.bcp.2009.01.017 View full text
Angelo Theodoratos, Wen Juan Tu, Jean Cappello, Anneke C. Blackburn, Klaus Matthaei, Philip G. Board

Abstract: Glutathione transferase Zeta (GSTZ1-1) is identical to maleylacetoacetate isomerase and catalyses a significant step in the catabolism of phenylalanine and tyrosine. Exposure of GSTZ1-1 deficient mice to high dietary phenylalanine causes a rapid loss of circulating white blood cells (WBCs). The loss was significant (P<0.05) after 2 days and total WBCs were reduced by 60% after 6 days. The rapid loss of WBCs was attributed to the accumulation of the catabolic intermediates maleylacetoacetate or maleylacetone (M…

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