Phenylalanine and Tyrosine in Collagen Diseases

Nishimura, Naoyuki

doi:10.1001/archderm.1961.01580100108015

Cited by 24 publications

(3 citation statements)

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“…However, TAT is a key enzyme of tyrosine metabolism, and increase in blood tyrosine levels were described by some researchers in a number of diseases (64,(74)(75)(76)(77)(78). In the works [79,80,88,89] published in Russian it was shown that blood tyrosine can be used as an index of GC action on metabolism and thus to be promising as a laboratory parameter for monitoring GC therapy.…”

Section: Discussionmentioning

confidence: 99%

“…In the late 1950s, Japanese researchers found increased levels of tyrosine in blood and urine of patients with collagen diseases and supposed that disorders in metabolism of this amino acid could be a biochemical basis of these pathologies [74,75]. These findings stimulated many studies on tyrosine metabolism in various diseases, and during some next years, an increase in blood tyrosine levels was recorded in patients with acute leukemia, acute pneumonia, acute peritonitis, rheumatism, and collagenoses without the pronounced liver damage in the majority of cases.…”

Section: Subjects Under Studymentioning

confidence: 99%

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Blood tyrosine determination for monitoring glucocorticoid therapy

Rass¹

2021

GSC Biol. and Pharm. Sci.

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Glucocorticoid (GC) preparations are used in medicine for more than 70 years as the most powerful anti-inflammatory drugs also possessing immunosuppressive, anti-allergic, and antitoxic properties. However, administration of these unique preparations is associated with nearly inevitable severe adverse effects and a difficulty of their withdrawal. These adverse effects are caused not by toxicity of GC preparations, but are manifestations of their hormonal features. GC preparations are synthetic analogs of GC hormones which directly or indirectly participate in the regulation of virtually all reactions and processes in the body. Nevertheless, in clinical practice there is no index of tissue provision with GCs and real need in these hormones (or preparations). In this paper, blood tyrosine level was shown to characterize the tissue provision with GCs on two models: adrenalectomy in rats and the replacement GC therapy in congenital adrenal hyperplasia. Determination of blood tyrosine level made it possible to reveal the insufficiency of tissue provision with GGs in patients with bronchial asthma during the period of attacks. In patients with systemic lupus erythematosus, GC preparations were shown to be favorable on the background of increased blood tyrosine, i.e. on the insufficient tissue provision with GCs, and until the normalization of blood tyrosine, i.e. until the compensation of the hormonal insufficiency. On the background of normal blood tyrosine GC preparations in SLE were ineffective and side effects appeared rapidly. These observations allowed me to propose blood tyrosine level as a laboratory parameter for monitoring GC therapy. The present paper consists of two parts: I) short reviews of the literature prerequisites for the proposal; II) the description of the author’s studies on blood tyrosine behavior in comparison with delivery and efficiency of glucocorticoid hormones or preparations in experiment (adrenalectomy in rats) and in some pathologies: congenital adrenal hyperplasia, bronchial asthma, and systemic lupus erythematosus.

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Section: Discussionmentioning

confidence: 99%

Section: Subjects Under Studymentioning

confidence: 99%

Blood tyrosine determination for monitoring glucocorticoid therapy

Rass¹

2021

GSC Biol. and Pharm. Sci.

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show abstract

“…In the late 1950s Japanese researchers of the Nishimura group found increased levels of tyrosine in blood and urine of patients with collagen diseases (Nishimura et al, 1958;Nishimura et al, 1961) and supposed that disorders in tyrosine catabolism could be a biochemical basis of these diseases. These reports stimulated intensive studies on tyrosine catabolism in collagenoses and some other diseases, especially in Russia.…”

Section: Blood Tyrosine Levels In Some Non-endocrine Diseasesmentioning

confidence: 99%