Phenotyping Occupational Asthma Caused by Acrylates in a Multicenter Cohort Study

Suuronen, Katri; Seed, Martin; Godet, Julien; Vandenplas, Olivier; Vandenplas,; Rifflart, Catherine; Klusáčková, Pavlína; Sherson, David; Suojalehto, Hille; Lindström, Irmeli; Hölttä, Pirjo; Kauppi, Paula; Blay, F. De; Hurdubaea, Laura; Merget, R.; Preisser, Alexandra M.; Harth, Volker; Maestrelli, Piero; Mason, Paola; Moscato, Gianna; Pignatti, Patrizia; Paggiaro, Pierluigi; Talini, D; DellʼOmo, Marco; Foletti, Ilenia; Svanes, Cecilie; Kirkeleit, Jorunn; Walusiak‐Skorupa, Jolanta; Wiszniewska, Marta; Muñoz, Xavier; Romero‐Mesones, Christian; Sastre, Joaquı́n; Fernández‐Nieto, Mar; Quirce, Santiago; Sánchez‐Jareño, Marta; Cullinan, Paul; Cannon, Julie; Burge, Sherwood; Moore, Vicky; Hoyle, Jennifer

doi:10.1016/j.jaip.2019.10.017

Cited by 28 publications

(15 citation statements)

References 35 publications

(44 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Isolated late reactions after exposure to diisocyanates are particularly well described [ 33 ]. In contrast, acrylates typically cause exposure-congruent symptoms, initially with rhinitis, conjunctivitis and urticaria [ 37 ]. However, even with diisocyanates, a reaction beginning later than 2 hours after the end of exposure is extremely rare [ 33 ].…”

Section: Evaluation and Interpretation Of The Test Resultsmentioning

confidence: 99%

Workplace-related inhalation test (AIT) – Specific inhalation challenge (SIC) – S2k Guideline of the German Society for Occupational and Environmental Medicine e.V. (DGAUM), the German Society for Pneumology and Respiratory Medicine e.V. (DGP)

Preisser¹,

Koschel²,

Merget³

et al. 2021

ALS

Self Cite

View full text Add to dashboard Cite

show abstract

Section: Evaluation and Interpretation Of The Test Resultsmentioning

confidence: 99%

Workplace-related inhalation test (AIT) – Specific inhalation challenge (SIC) – S2k Guideline of the German Society for Occupational and Environmental Medicine e.V. (DGAUM), the German Society for Pneumology and Respiratory Medicine e.V. (DGP)

Preisser¹,

Koschel²,

Merget³

et al. 2021

ALS

Self Cite

View full text Add to dashboard Cite

show abstract

“…A Finnish study found that over 60% of occupational asthma and more that 20% of occupational rhinitis was associated with methacrylate materials in dental personnel 33 . In addition, further studies reinforce that daily methacrylate use has been associated with adult‐onset asthma, rhinitis, and conjunctivitis in dental personnel 32,35,37,38,76 with a reported prevalence estimate ranging from 1.3% to 14% 31 . Moreover, prevalence studies suggest a possible increasing trend with methacrylate sensitivity with estimates ranging from 1.3% to 25% in dental workers 18,31,46,77 .…”

Section: Respiratory Issuesmentioning

confidence: 94%

Methacrylate perspective in current dental practice

Bishop

Roberts

2020

J Esthet Restor Dent

View full text Add to dashboard Cite

Objective: To provide a current perspective concerning dental personnel sensitivity to methacrylate materials. Overview: Methacrylate related sensitivity and allergies are currently beyond traditional thoughts concerning denture base resins and methyl methacrylate provisional materials. Methacrylates are now ubiquitous in current dental practice and dental personnel should be aware that dental adhesives contain potent sensitizers that may also cross-sensitize individuals to other methacrylates not experienced. The growing sensitivity to 2-hydroxyethyl methacrylate (HEMA) has been described to be epidemic in nature due to the artificial nail industry with dental patients and dental personnel may be more susceptible to dental methacrylate sensitization. While contact dermatitis remains the most prevalent methacrylate-related clinical presentation, respiratory complications and asthma are increasing associated with methacrylate exposure. While additional personal protective equipment (PPE) is thought to be first protective choice, the National Institute for Occupational Safety and Health (NIOSH) considers PPE overall largely ineffective and should be considered only as a last resort. Conclusion: Dental personnel need to be more aware of methacrylate sources and use workplace control measures to limit methacrylate exposures to both dental personnel and patients. Clinical Significance: Sensitivity to methacrylate materials is a growing dental workplace major concern and dental personnel should be aware of both the methacrylate content of current materials and the products that contain ingredients with the most sensitization potential.

show abstract

“…This inflammation leads to episodes repeated, particularly at night or early morning, lead to airway lightness and the coughing of susceptible people. The incidents usually involve significant but unpredictable airflow barriers, often reversible or therapeutic spontaneously [19,20]. The inflammation also raises the current bronchial hyperreactive to a variety of stimuli.…”

Section: Introductionmentioning

confidence: 99%

Inhibition Effect of Copper (II) Theophylline Nanocomplex on Phosphodiesterase (PDE) Enzyme Activity in Human Serum of Iraqi Patients with Asthma Disease

Abbas¹,

Ismail²,

Al-Bairmani³

et al. 2021

Nano BioMed ENG

View full text Add to dashboard Cite

Copper (II) theophylline [Cu(THP) 2 (H 2 O) 4 ] complex in nanoscale has synthesized by ultrasonic sonication method. This method was used in the development of smaller, dispersed, and unaggregated nanoparticles (NPs). The structure of nanocomplex was described and suggested by the molar conductance, Fourier transform infrared spectroscopy (FTIR), ultraviolet-visible spectroscopy (UV-Vis), solubility, atomic fire absorption, and C.H.N. elemental analysis as octahedral geometry. The size and morphology of nanocomplex measured by transmission electron microscopy (TEM) were 20 nm. The nanocomplex was studied on phosphodiesterase enzyme activity in human serum of Iraqi patient›s asthma disease. The results showed a highly significant (p < 0.01) increase in the serum levels of phosphodiesterase enzyme activity in asthma patients (mean = 14.939 ± 3.021 ng/mL) compared with a control group (mean = 9.974 ± 2.032 ng/mL). The result also showed a highly significant (p < 0.01) decrease in the serum levels of phosphodiesterase activity in patients of asthma disease with theophylline (mean = 11.253 ± 2.479 ng/mL) compared to serum patients without nano and control groups. It is vital that the result showed a highly significant (p < 0.01) decrease in the serum levels of phosphodiesterase activity in patients of asthma disease with copper nano complex (mean = 9.563 ± 2.082 ng/mL) compared in patients of asthma disease with and without theophylline. As for comparing asthma disease with copper nano complex and control group, the result showed there was no significant effect (p > 0.05).

show abstract

Phenotyping Occupational Asthma Caused by Acrylates in a Multicenter Cohort Study

Cited by 28 publications

References 35 publications

Workplace-related inhalation test (AIT) – Specific inhalation challenge (SIC) – S2k Guideline of the German Society for Occupational and Environmental Medicine e.V. (DGAUM), the German Society for Pneumology and Respiratory Medicine e.V. (DGP)

Workplace-related inhalation test (AIT) – Specific inhalation challenge (SIC) – S2k Guideline of the German Society for Occupational and Environmental Medicine e.V. (DGAUM), the German Society for Pneumology and Respiratory Medicine e.V. (DGP)

Methacrylate perspective in current dental practice

Inhibition Effect of Copper (II) Theophylline Nanocomplex on Phosphodiesterase (PDE) Enzyme Activity in Human Serum of Iraqi Patients with Asthma Disease

Contact Info

Product

Resources

About