volume 191, issue 4, P1578-1585 2013
DOI: 10.4049/jimmunol.1300424
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Fabrice Lemaître, Hélène D. Moreau, Laura Vedele, Philippe Bousso

Abstract: International audienceEffector T cell responses rely on a phenotypically and functionally heterogeneous population of cells. Whether this diversity is programmed before clonal expansion or in later phases as a result of stochastic events or asymmetric cell division is not fully understood. In this study, we first took advantage of a sensitive in vitro assay to analyze the composition of single CD8(+) T cell progenies. Heterogeneity was predominantly observed between progenies of distinct clones, but could also…

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