“…The conditions chosen for investigation all show hyperkeratosis, namely, keratosis pahnaris et plantaris, ichthyosis and pachyonychia for which no cause could be fonnd and which appeared to be congenital in type, though no abnormality other than thickening of the nails was present; thus differing from " Pachyonychia congenita " in which A'itamin A was said to be normal by Wise (1948) and by Garb (1950).…”