Phenolics, tannins, flavonoids and anthocyanins contents influenced antioxidant and anticancer activities of Rubus fruits from Western Ghats, India

Muniyandi, Kasipandi; George, E. Olusȩgun; Sathyanarayanan, Saikumar; George, Blassan P.; Abrahamse, Heidi; Thakur, Suman; Thangaraj, Parimelazhagan

doi:10.1016/j.fshw.2019.03.005

Cited by 83 publications

(53 citation statements)

References 23 publications

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“…This finding may be explained by the FRAP activity being based on the reducing power of the sample, where the aromatic hydroxyl group in flavonoid compounds acts as an excellent reducing agent. These findings were, therefore, consistent with those of a previous study, in which a correlation between the TF content and FRAP activity was reported [24] The interaction between X 1 and X 2 or X 3 was shown to have a significant effect on the TF content, and although lower values of X 1 and X 2 resulted in an increase in the TF content, a high value of X 3 with a low value of X 1 resulted in an increase in the FRAP activity. In addition, the interaction between X 1 and X 4 was shown to produce a maximum value at 12 h, which is the center of the response model; however, the interactions of X 12 and X 13 were shown to be stronger.…”

Section: Effect Of Extraction Variables On Frapsupporting

confidence: 93%

Dendropanax morbifera Leaf Polyphenolic Compounds: Optimal Extraction Using the Response Surface Method and Their Protective Effects against Alcohol-Induced Liver Damage

Eom

Kim

2020

Antioxidants

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The response surface methodology was used to optimally extract the antioxidant substances from Dendropanax morbifera leaves. The central composite design was used to optimally analyze the effects of ethanol concentration, sample to solvent ratio, extraction temperature, and extraction time on the total flavonoids (TF) content, ferric reducing antioxidant power (FRAP), and Trolox equivalent antioxidant capacity (TEAC). All three parameters were largely influenced by the ethanol concentration and extraction temperature, while TEAC was also influenced by the sample to solvent ratio. The maximum values of TF content, FRAP, and TEAC were achieved under the following extraction conditions: 70% ethanol, 1:10 sample to solvent ratio, 80 °C, and 14 h. The D. morbifera leaf extracts (DMLE) produced under these optimum extraction conditions were investigated to determine their preventive effects on alcohol-induced liver injury. The DMLE was shown to prevent liver injury by scavenging the reactive oxygen species generated by alcohol. In addition, composition analysis of DMLE found high contents of chlorogenic acid and rutin that were determined to inhibit alcoholic liver injury. The findings of this study suggest that DMLE could prove useful as a functional food product supplement to prevent liver injury caused by excessive alcohol consumption.

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Section: Effect Of Extraction Variables On Frapsupporting

confidence: 93%

Dendropanax morbifera Leaf Polyphenolic Compounds: Optimal Extraction Using the Response Surface Method and Their Protective Effects against Alcohol-Induced Liver Damage

Eom

Kim

2020

Antioxidants

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“…There was undetected to fairly low flavonoid content in the aqueous extracts of M. sinensis and M. paradisiaca in this study. However, the flavonoid content in M. paradisiaca boiled peel extract in this study is comparable to the observation in the aqueous extract of Rubus niveus fruit [ 57 ] and is also comparable to similar pharmacological profiles such as antiproliferative, antioxidant, and enzyme inhibitory activities of Rubus caesius L. [ 58 , 59 ]. Generally, the higher phytochemical contents detected in the acetone and ethanol extracts over the aqueous extracts of M. sinensis and M. paradisiaca fruits suggest the superior extractive potency of organic solvents over the somewhat weaker potency in aqueous solvents [ 60 ].…”

Section: Correlation Between Phytochemical Constituents and Antioxsupporting

confidence: 86%

Comparative and Correlational Evaluation of the Phytochemical Constituents and Antioxidant Activity of Musa sinensis L. and Musa paradisiaca L. Fruit Compartments (Musaceae)

Oyeyinka

Afolayan

2020

The Scientific World Journal

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Secondary metabolites and their biological activity have pharmacological relevance in the prevention and therapeutic management of disease, including the facilitation of normal physiological processes through biochemical mechanisms. In this study, phytochemical constituents and antioxidant activity were evaluated quantitatively on the acetone, ethanol, and aqueous extracts of the flesh, and peel, as well as the boiled peel extract compartments of Musa sinensis L. and Musa paradisiaca L. fruits. Total phenol, proanthocyanidin, and flavonoid contents were estimated and measured spectrophotometrically. The free radical scavenging antioxidant capacity of the extracts was tested on DPPH (2,2-diphenyl-1-picrylhydrazyl ethanol), ABTS (2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid)), and FRAP (ferric reducing antioxidant power) assay models. Correlation between phytoconstituents and antioxidant activity was analysed using Pearson’s coefficient. The results showed varying amounts of phytochemicals in the solvent extracts of the flesh and peel, including the boiled peel extract of M. sinensis and M. paradisiaca. All acetone extracts of M. sinensis flesh, M. paradisiaca flesh, and M. paradisiaca peel had the highest phytochemical contents, with the exception of the ethanol extract of M. sinensis peel which had the highest phenol content; just as on the overall scale, the peel compartments had generally higher phytochemical profiles than the soft flesh in both fruits. The boiled peel extracts of M. sinensis and M. paradisiaca had the highest ABTS (0.03 mg/mL) and DPPH (0.03 mg/mL) activity. Ferric reducing power (FRAP) was the highest in the ethanol extracts of M. sinensis flesh and peel, and M. paradisiaca flesh, while it was the highest in the acetone extract of M. paradisiaca at the peak concentration used (0.1 mg/mL). There was a significant negative correlation between the total phenol and flavonoid contents of M. sinensis flesh with its DPPH radical scavenging activity and proanthocyanidin content of M. paradisiaca flesh with its DPPH radical scavenging activity. The correlation outcomes indicate that none of the phytochemical constituents solely affected antioxidant activity; instead, a combination of the polyphenolic constituents contributed to antioxidant activity. This study shows the therapeutic potentials of the flesh and, importantly, the peel of M. sinensis and M. paradisiaca fruits on the basis of the polyphenolic constitution against free radicals and oxidative stress.

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“…Summarizing the above results, we found that all the extracts have certain antioxidant activity and wICM showed better antioxidant activity in all tests, except for the DPPH assay. Previous studies showed that the contents of phenolic acids and flavonoids are positively correlated with antioxidant capacity [63]. However, the content of various components in mICM was the highest in the component quantification section of this paper.…”

Section: Discussionmentioning

confidence: 58%

Phytochemical Analysis, Antioxidant and Analgesic Activities of Incarvillea compacta Maxim from the Tibetan Plateau

et al. 2019

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Incarvillea compacta Maxim is a traditional Tibetan plant widely used to treat rheumatic pain and bruises. We conducted qualitative analyses by liquid chromatography-mass spectrometry and quantitative analyses of the total phenols, flavonoids, and alkaloids content of different extracts of I. compacta Maxim. Antioxidant and analgesic activity were analyzed. The results showed that the methanol extract had the highest content of the various ingredients. A total of 25 constituents were identified, of which compounds 1–23 were found for the first time in this plant. The water extract had the highest capacity to clear free radicals in the antioxidant test. The water extract had dose-dependent analgesic effects in the first and second phase in a formalin test. The latency of pain from a hot-plate test was augmented by the water extract when the dose was greater than or equal to 30 g/kg. The water extract significantly decreased the amount of writhing in a dose-dependent manner compared with the control group in the acetic acid-induced writhing test. These results showed that I. compacta Maxim is a new antioxidant and analgesic agent, and this study provides information on its ingredients for further study.

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Phenolics, tannins, flavonoids and anthocyanins contents influenced antioxidant and anticancer activities of Rubus fruits from Western Ghats, India

Cited by 83 publications

References 23 publications

Dendropanax morbifera Leaf Polyphenolic Compounds: Optimal Extraction Using the Response Surface Method and Their Protective Effects against Alcohol-Induced Liver Damage

Dendropanax morbifera Leaf Polyphenolic Compounds: Optimal Extraction Using the Response Surface Method and Their Protective Effects against Alcohol-Induced Liver Damage

Comparative and Correlational Evaluation of the Phytochemical Constituents and Antioxidant Activity of Musa sinensis L. and Musa paradisiaca L. Fruit Compartments (Musaceae)

Phytochemical Analysis, Antioxidant and Analgesic Activities of Incarvillea compacta Maxim from the Tibetan Plateau

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