Phenolic content, antibacterial, antioxidant, and toxicological investigations of Erodium guttatum (Geraniaceae) collected from the Northeast of Morocco

Mrabti, Hanae Naceiri; Doudach, Latifa; Kachmar, Mohamed Reda; Ed-Dra, Abdelaziz; Khalil, Z.H.; Mrabti, Nidal Naceiri; Benrahou, Kaoutar; Harraqui, Khouloud; Zengin, Gökhan; Bouyahya, Abdelhakim; Faouzi, My El Abbés

doi:10.3906/bot-2107-29

Cited by 9 publications

(5 citation statements)

References 40 publications

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“…The antioxidant activity of the two tested EOs was evaluated using the following three commonly used in vitro complementary assays: DPPH, H 2 O 2 , and xanthine oxidase (XO) methods, and following the same procedures as described previously by the research group [ 25 – 27 ]. Each assay was carried out in triplicate, and allopurinol and ascorbic acid were used as positive controls.…”

Section: Methodsmentioning

confidence: 99%

Determination of Volatile Compounds of Mentha piperita and Lavandula multifida and Investigation of Their Antibacterial, Antioxidant, and Antidiabetic Properties

Al-Mijalli

Elsharkawy

Abdallah

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Mentha piperita and Lavandula multifida are widely used in Moroccan traditional medicine for the treatment of diabetes and infectious diseases. The aims of this work were the determination of the chemical composition of Mentha piperita (MPEO) and Lavandula multifida (LMEO) essential oils and the evaluation of their antibacterial, antioxidant, and antidiabetic activities. The chemical composition was determined by GC-MS analysis. The antibacterial effects were evaluated against several bacterial strains using disc diffusion, MIC, and MBC methods. The antioxidant activity was evaluated in vitro using DPPH, H2O2, and xanthine oxidase, and the antidiabetic activity was estimated by the inhibitory effects of α-amylase, α-glucosidase, and lipase activities. GC-MS results showed that the main compounds of MPEO were menthone (29.24%), levomenthol (38.73%), and eucalyptol (6.75%). However, eucalyptol (28.11%), 2-bornanone (11.57%), endo-borneol (7.82%), and linalyl acetate (5.22%) are the major compounds of LMEO. The results exhibited important inhibitory effects against some bacterial strains with MIC = MBC = 0.39 mg/mL for MPEO against Staphylococcus aureus ATCC. However, LMEO exhibited remarkable antioxidant and antidiabetic activities compared to MPEO. Indeed, LMEO inhibited DPPH, H2O2, and xanthine oxidase with concentrations of 15.23, 21.52, and 8.89 µg/mL, respectively. Moreover, LMEO exhibited α-amylase and α-glucosidase at IC50 = 85.34 and IC50 = 59.36 µg/mL, respectively. The findings showed that both MPEO and LMEO exhibit promising biological properties. However, the application of these species or their main bioactive compounds requires further investigation.

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Section: Methodsmentioning

confidence: 99%

Determination of Volatile Compounds of Mentha piperita and Lavandula multifida and Investigation of Their Antibacterial, Antioxidant, and Antidiabetic Properties

Al-Mijalli

Elsharkawy

Abdallah

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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“…Indeed, studies have confirmed the richness of the extracts of E. guttatum in phenolic compounds. It has also been shown to have antioxidant activity by DPPH, H2O2, and xanthine oxidase assays [ 30 , 31 ].…”

Section: Discussionmentioning

confidence: 99%

Inhibition of α-Amylase, α-Glucosidase, and Lipase, Intestinal Glucose Absorption, and Antidiabetic Properties by Extracts of Erodium guttatum

Benrahou

Mrabti

Bouyahya

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Erodium guttatum is widely used in traditional medicine to treat various diseases, including diabetes. In this study, we evaluated in vitro inhibitory activity of extracts of E. guttatum on α-amylase, α-glucosidase, and lipase and then studied in vivo using different animal models. The results showed that the aqueous and alcoholic extracts of E. guttatum significantly inhibited digestive enzymes. The extracts of E. guttatum significantly reduced postprandial hyperglycemia after starch loading in normal rats. Additionally, extracts of E. guttatum significantly decrease the intestinal absorption of D-glucose. However, the methanolic extract of E. guttatum showed remarkable antidiabetic activity compared to the aqueous and ethanolic extracts of E. guttatum. In addition, the extracts significantly reduced blood sugar levels in albino mice and hematological and biochemical profiles. Therefore, the results of this study show that the extracts of E. guttatum have antidiabetic effects and could therefore be suggested in the management of type 2 diabetes.

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“…The antioxidant capacity of the MPEO, thyme honey and their mixture was evaluated through three well-established in vitro assays: DPPH●, H 2 O 2 , and xanthine oxidase (XO) tests, following the protocols established by the research team in previous studies [ [32] , [33] , [34] ]. Each experiment was repeated three times, using allopurinol and ascorbic acid as positive controls.…”

Section: Methodsmentioning

confidence: 99%

Unlocking the combined action of Mentha pulegium L. essential oil and Thym honey: In vitro pharmacological activities, molecular docking, and in vivo anti-inflammatory effect

Assaggaf,

El Hachlafi,

Elbouzidi

et al. 2024

Heliyon

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Phenolic content, antibacterial, antioxidant, and toxicological investigations of Erodium guttatum (Geraniaceae) collected from the Northeast of Morocco

Cited by 9 publications

References 40 publications

Determination of Volatile Compounds of Mentha piperita and Lavandula multifida and Investigation of Their Antibacterial, Antioxidant, and Antidiabetic Properties

Determination of Volatile Compounds of Mentha piperita and Lavandula multifida and Investigation of Their Antibacterial, Antioxidant, and Antidiabetic Properties

Inhibition of α-Amylase, α-Glucosidase, and Lipase, Intestinal Glucose Absorption, and Antidiabetic Properties by Extracts of Erodium guttatum

Unlocking the combined action of Mentha pulegium L. essential oil and Thym honey: In vitro pharmacological activities, molecular docking, and in vivo anti-inflammatory effect

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