Phenolic compounds from the flowers of Garcinia dulcis

Deachathai, Suwanna; Mahabusarakam, Wilawan; Phongpaichit, Souwalak; Taylor, WC; Yj, Zhang; Chang, Yang Lang

doi:10.1016/j.phytochem.2005.10.016

Cited by 53 publications

(38 citation statements)

References 11 publications

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“…We then tested each of the compounds 10, 14 and their 1 : 1 mixture. Interestingly, the 1 : 1 mixture of compounds 10 and 14 significantly increased the antibacterial activities against B. subtilis, S. aureus, E. faecalis, MRSA and VRE compared with the pure forms (10,14). From this result, it may be possible that a 1 : 1 mixture of compounds 10 and 14 showed synergism effect for antibacterial activity against all Gram-positive bacteria tested.…”

Section: Resultsmentioning

confidence: 86%

“…pruniflorum was subjected to chemical investigation leading to the isolation of two new xanthones, pruniflorone K (1) and L (2), together with thirteen known xanthones identified as cochinchinone A (3), 11) formoxanthone B (4), 8) 1,7-dihydroxy-8-methoxyxanthone (5), 12) cochinchinone I (6), 10) 1,3,7-trihydroxy-2,4-diisoprenylxanthone (7), 13) celebixanthone methyl ether (8), 14) vieillardiixanthone B (9), 15) macluraxanthone (10), 16) dulcisxanthone B (11), 17) norcowanin (12), 18) 5,9-dihydroxy-8-methoxy-2,2-dimethyl-7-(3-methylbut-2-enyl)-2H,6H-pyrano [3,2b]xanthone (13), 19) Garcinone B (14), 20) and brasilixanthone (15). 21) Their structures were elucidated by NMR analysis and comparison of their spectroscopic data with those reported in the literatures.…”

Section: Resultsmentioning

confidence: 99%

“…pruniflorum had resulted in nine new and nine known xanthones. 7) Herein, this paper describes further investigation of CH 2 Cl 2 extract from the roots of the same plant which led to the isolation of two new xanthones (1, 2) along with thirteen known xanthones (3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15). In addition, the antibacterial and antifungal activities were also evaluated.…”

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Chromene and Prenylated Xanthones from the Roots of Cratoxylum formosum ssp. pruniflorum

Boonnak

Karalai

Chantrapromma

et al. 2010

CHEMICAL & PHARMACEUTICAL BULLETIN

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Section: Resultsmentioning

confidence: 86%

Section: Resultsmentioning

confidence: 99%

mentioning

confidence: 99%

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Chromene and Prenylated Xanthones from the Roots of Cratoxylum formosum ssp. pruniflorum

Boonnak

Karalai

Chantrapromma

et al. 2010

CHEMICAL & PHARMACEUTICAL BULLETIN

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“…The physico-chemical properties of garciniaxanthone I (1) and garcinane (2) [3]. The absorption bands at 3460, 1660, and 1627 cm Ϫ1 in the IR spectrum suggested a xanthone skeleton with a chelated hydroxyl group [15].…”

Section: Physico-chemical Propertiesmentioning

confidence: 99%

Antimalarial Compounds from the Root Bark of Garcinia polyantha Olv.

et al. 2008

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Eight compounds were isolated from the roots of Garcinia polyantha, and identified. Two of them, the xanthone garciniaxanthone I (1), and the triterpene, named garcinane (2), are reported as new natural products. The structures of the new compounds were elucidated on the basis of 1D and 2D NMR spectroscopic studies. The structure of compound 1 was confirmed by Xray crystallography. Among the remaining six known compounds, three were known xanthones [smeathxanthone A (3), smeathxanthone B (4), and chefouxanthone (5)], one benzophenone [isoxanthochymol (6)], one triterpene [magnificol], and one sterol [b -sitosterol]. The in vitro antimalarial activity of isoxanthochymol (6) against Plasmodium falciparum shows strong chemosuppression of parasitic growth.Keywords Garcinia polyantha, garciniaxanthone I, Xray crystallography, xanthones; antimalarial activity IntroductionThe genus Garcinia of the Guttiferae family is well known to be a rich source of bioactive prenylated xanthones [1ϳ3], triterpenes [4], and benzophenones [5,6]. In continuation of our search for bioactive substances from African medicinal plants, we investigated the methanol extract of the root bark of Garcinia polyantha, a tree distributed in the lowland tropical rainforest of West, East and Central Africa [7,8]. In the current investigation we focused on minor constituents from G. polyantha, and one new xanthone (1), one new triterpene (2), and six known compounds (3ϳ6, magnificol, and b -sitosterol), were isolated (Fig. 1). We report herein the structure elucidation of the eight natural products and their antimalarial activity. Materials and Methods General Experimental ProceduresMelting points were determined on a Büchi SMP-20 melting point apparatus and are uncorrected. UV spectra were measured with a UV-210 PC UV. IR spectra were recorded on a SHIMADZU FTIR-8400S spectrometer in KBr disks. EI-MS (ionization voltage 70 eV) and HR-EI-MS mass spectra were recorded on Finnigan MAT double focusing spectrometer Model 8230. 1 H-and 13 C-NMR spectra were recorded with a Bruker Avance 500 MHz NMR spectrometer in CDCl 3 or CDCl 3 /CD 3 OD. Chemical shifts are recorded relative to TMS (dϭ0) internal standard and coupling constants J are reported in Hz. Optical rotation were recorded with a Perkin-Elmer 241

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“…Possui distribuição pantropical, incluindo 40-50 gêneros como Vismia (Nguemeving et al, 2006), Garcinia (Deachathai et al, 2006), Clusia (Dias et al, 2006), Cratoxylum (Boonsri et al, 2006) Harungana (Tih et al, 2006), Mesua (Uawonggul et al, 2006), Hypericum (Mártonfi et al, 2006), Kielmeyera (Zagoto et al, 2006) e mais de 1000 espécies distribuídas em 6 subfamílias. No Brasil ocorrem 21 gêneros e 183 espécies, com ampla distribuição (Barroso et al, 2002).…”

Section: Introductionunclassified

Estudo farmacobotânico das folhas de Garcinia brasiliensis Mart. (Clusiaceae)

Santa-Cecília

Abreu

Silva³

et al. 2013

Rev. bras. plantas med.

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RESUMO:A espécie Garcinia brasiliensis Mart. (Clusiaceae), nativa da região Amazônica e cultivada em todo o território brasileiro, vem sendo bastante estudada devido seu potencial farmacológico, porém são escassos estudos que tratam da caracterização farmacobotânica desta espécie. Considerando as propriedades terapêuticas para tornar-se um medicamento fitoterápico, o presente trabalho teve como objetivos estudar a anatomia e histoquímica da folha e do pecíolo e elaborar dados macroscópicos e microscópicos que forneçam características marcantes para sua identificação além de dar subsídios para a análise farmacognóstica no controle de qualidade da droga vegetal. O material vegetal foi fixado e submetido às técnicas usuais de microscopia de luz e a testes histoquímicos. As folhas de G. brasiliensis são opostas, simples, descolores, forma elíptica com nervação peninérvia. As células epidérmicas, em vista frontal, apresentam contorno sinuoso e estômatos paracíticos somente na face abaxial. O mesofilo é dorsiventral, a nervura central apresenta contorno biconvexo e feixe vascular em forma de semi-arco fechado envolto por bainha esclerenquimática. Inclusões inorgânicas de cristais na forma de drusas e orgânicas representadas por compostos fenólicos e grãos de amidos estão dispersos ao longo de toda lâmina foliar e pecíolo. Observa-se com frequência a presença de canais secretores preenchidos por um conteúdo lipídico dispersos pelo parênquima fundamental e próximos aos feixes vasculares. Estes dados fornecem subsídios para o controle de qualidade da matéria-prima utilizada para a produção de fitoterápicos.Palavras-chave: bacupari, Garcinia brasiliensis, Clusiaceae, morfodiagnose ABSTRACT: Pharmacobotanical studies of Garcinia brasiliensis Mart. (Clusiaceae) leaves. The Garcinia brasiliensis Mart. (Clusiaceae) species, native of the Amazon region and cultivated throughout the Brazilian territory, has been widely studied due to its pharmacological potential, but there are few studies dealing with the pharmacobotanic characterization of this species. Considering the therapeutic properties in order to become an herbal medicine, the present paper had the purpose of studying the anatomical and histochemical characterization of the leaf and petiole, as well as producing macroscopic and microscopic data that provide important characteristics for its identification, in addition to providing subsidies for the pharmacognostical analysis in order to offer elements for the quality assurance of the drug. The botanical material was prepared through the usual optical and histochemical microtechniques. The leaves of G. brasiliensis are simple, opposed, colorless, and they show an elliptical shape. As seen from the front, the epidermal cells have a sinuous contour, and paracytic stomata occur on the low surface. The leaves are hipostomatic and dorsiventral with heterogeneous mesophile. The mesophile is dorsiventral, the central midrib shows a biconvex contour and vascular system in a semi-closed arch shape surrounded by a sclerenchymatic...

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Phenolic compounds from the flowers of Garcinia dulcis

Cited by 53 publications

References 11 publications

Chromene and Prenylated Xanthones from the Roots of Cratoxylum formosum ssp. pruniflorum

Chromene and Prenylated Xanthones from the Roots of Cratoxylum formosum ssp. pruniflorum

Antimalarial Compounds from the Root Bark of Garcinia polyantha Olv.

Estudo farmacobotânico das folhas de Garcinia brasiliensis Mart. (Clusiaceae)

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