Phenolic compounds and methylglyoxal in some New Zealand manuka and kanuka honeys

Stephens, Jonathan M.; Schlothauer, Ralf C.; Morris, Bret A.M.; Yang, Derek; Fearnley, Liam; Greenwood, David R.; Loomes, Kerry M.

doi:10.1016/j.foodchem.2009.09.074

Cited by 178 publications

(196 citation statements)

References 28 publications

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“…However, previous studies indicate that this compound does not correlate with non-peroxide activity [20,21]. Additionally, methyl syringate concentration has also been reported as elevated in kanuka honeys (K. ericoides) and is higher than that reported in manuka honeys [7,10]. Accordingly, methyl syringate may not be a suitable chemical marker for manuka honey.…”

Section: Introductionmentioning

confidence: 90%

“…Methyl syringate concentration is elevated in manuka and kanuka honeys in New Zealand [7,10]. The linear correlation ( Figure 5B) of Leptosperin and methyl syringate concentrations is poor (R 2 = 0.1704).…”

Section: -Methoxyacetophenone and Methyl Syringatementioning

confidence: 98%

“…Many of these have received atention [7][8][9][10][11], and clearly, this honey carries a number of distinct compounds that may be diagnostic for classiication. For example, 2-methoxyacetophenone (Figure 1) [7,11] and 2-methoxybenzoic acid [10,11] have been proposed as loral markers for manuka honey.…”

Section: Introductionmentioning

confidence: 99%

“…As phenolic and polyphenolic compounds have been described as reliable indicators of botanical and geographical origin of honeys [10,16,34,35]; the luorescence properties of these intrinsic and unique luorophores may inform identiication of loral source reliably.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Fluorescence: A Novel Method for Determining Manuka Honey Floral Purity

Stephens¹,

Loomes²,

Braggins³

et al. 2017

Honey Analysis

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Manuka honey, harvested from Leptospermum scoparium, is New Zealand's most recognised honey type and commands a premium due to health-related beneits. However, the plant's distribution, relative to other species lowering simultaneously, allows honeybees to incorporate alternative nectars into the honey. Melissopalynological analysis in New Zealand is often unrepresentative due to the presence of many pollen-bearing sources; consequently, alternative means of categorising manuka honey were examined. RP-HPLC revealed that manuka honey contains distinct compounds, of which were relatively enriched and not present in the other New Zealand monoloral honeys. These main candidate compounds were isolated and have been described by mass spectrometry and nuclear magnetic resonance, synthesised to conirm structure, and as standards. These compounds, Leptosperin and Lepteridine, are a methyl syringate glycoside and pteridine derivative, respectively. Examination of these compounds revealed unique luorescence signatures, this luorescence could be detected in manuka honey samples the signal used to conirm that a honey was solely or predominantly consisted of L. scoparium nectar. Commercial manuka honeys were assessed by traditional analytical techniques, and comparisons were made with luorescence signature; the luorescence technique determined the authenticity of the honeys accurately.

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Section: Introductionmentioning

confidence: 90%

Section: -Methoxyacetophenone and Methyl Syringatementioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Fluorescence: A Novel Method for Determining Manuka Honey Floral Purity

Stephens¹,

Loomes²,

Braggins³

et al. 2017

Honey Analysis

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“…The amount of each compound may be modifi ed after heating. In addition, the methoxylated compounds in Manuka honey diff er with the age of the honey (Stephens et al, 2010).…”

Section: Natural Antibioticmentioning

confidence: 99%

Biological applications of honeys produced by Apis mellifera

Montenegro

Mejías

2013

Biol. Res.

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Honey is a natural product with many attributes that are useful for humans. The consumption of honey is increasing because of its benefi cial biological properties, including antioxidant and antibacterial activities. Even though honey is produced worldwide, many variants of this product have not been studied and their biological potential for alternative uses has not been evaluated. Because of its varied endemic native fl ora, Chile produces several types of honey. It is likely that these apian products have important biological properties inherited from specifi c fl oral sources, but it is absolutely necessary to conduct further chemical analyses to identify and characterize these biological attributes. Sadly, the potential antimicrobial and antitumor activities of Chilean honeys remain unproven at the present time. Further studies are needed to identify these attributes. In addition, the impact of human activities on the natural production of honey by bees should be considered. The use of honey as an environmental marker of pollution should also be considered, and care must be taken to diminish the eff ect of industry and human procedures on natural environments

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Manuka honey sinus irrigations in recalcitrant chronic rhinosinusitis: phase 1 randomized, single‐blinded, placebo‐controlled trial

Ooi

Jothin

Bennett

et al. 2019

Int Forum Allergy Rhinol

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Background Manuka honey (MH) has significant antibiofilm activity in vitro and in vivo against Staphylococcus aureus, methicillin‐resistant S aureus (MRSA), and Pseudomonas aeruginosa. This is the first randomized, single‐blinded, placebo‐controlled phase 1 clinical trial investigating the safety and preliminary efficacy of MH with augmented methylglyoxal (MGO) rinses in recalcitrant chronic rhinosinusitis (CRS). Methods Patients were included after previously undergoing endoscopic sinus surgery and presenting with signs and symptoms of sinus infection with positive bacterial cultures on sinus swabs. Patients were randomized to receive 14 days of twice‐daily 16.5% MH + 1.3 mg/mL MGO sinonasal rinses and concurrent 10 days of placebo tablets (MH), or 14 days of twice‐daily saline sinonasal rinses and concurrent 10 days of culture‐directed antibiotic therapy (CON). Safety observations included the University of Pennsylvania Smell Identification Test (UPSIT) and adverse‐event (AE) reporting. Efficacy was assessed comparing microbiology results, Lund‐Kennedy scores (LKSs), and symptom scores using the visual analog scale (VAS) and 22‐item Sino‐Nasal Outcome Test (SNOT‐22). Results Twenty‐five patients completed the study. MH demonstrated a good safety profile with no major AEs and no changes in UPSIT. Six of 10 (60%) MH patients had a reduction in bacterial culture rate with 1 of 10 of those having negative cultures, compared with 12 of 15 (80%) in the control group with 7 of 15 having negative cultures upon completion of the study. Conclusion This study concludes that twice‐daily 16.5% MH augmented with 1.3 mg/mL MGO sinonasal rinses alone for 14 days is safe but not superior to culture‐directed oral antibiotics and twice‐daily saline rinses.

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Phenolic compounds and methylglyoxal in some New Zealand manuka and kanuka honeys

Cited by 178 publications

References 28 publications

Fluorescence: A Novel Method for Determining Manuka Honey Floral Purity

Fluorescence: A Novel Method for Determining Manuka Honey Floral Purity

Biological applications of honeys produced by Apis mellifera

Manuka honey sinus irrigations in recalcitrant chronic rhinosinusitis: phase 1 randomized, single‐blinded, placebo‐controlled trial

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