Phenobarbital Compared With Carbamazepine in Prevention of Recurrent Febrile Convulsions

Behavioral and Psychiatric Adverse Events Associated With Antiepileptic Drugs Commonly Used in Pediatric Patients

“…Identification of potentially relevant articles began with a series of literature searches performed in early 2004 using Figure 1. Antiepileptic drug use in pediatric epilepsy patients aged 0 through 19 years.' CBZ = carbamazepine; GBP = gabapentin; LEV = levetiracetam; LTG = lamotrigine; OXC = oxcarbazepine; PB = phenobarbital ; PHT = phenytoin; TPM = topiramate; VPA = valproic acid; ZNS = zonisamide.…”

Behavioral and Psychiatric Adverse Events Associated With Antiepileptic Drugs Commonly Used in Pediatric Patients

“…Identification of potentially relevant articles began with a series of literature searches performed in early 2004 using Figure 1. Antiepileptic drug use in pediatric epilepsy patients aged 0 through 19 years.' CBZ = carbamazepine; GBP = gabapentin; LEV = levetiracetam; LTG = lamotrigine; OXC = oxcarbazepine; PB = phenobarbital ; PHT = phenytoin; TPM = topiramate; VPA = valproic acid; ZNS = zonisamide.…”

Complex Febrile Seizures: An Update

“…54 In a double-blind trial of children with recurrent and/or CFS, only two (10%) of the children receiving phenobarbital had recurrences versus 47% of patients treated with carbamazepine, suggesting that carbamazepine is not as effective in preventing recurrences as phenobarbital. 55 Intermittent oral levetiracetam was found in one study to be efficacious in preventing febrile seizure recurrence with minimal side effects. 56 A recent systematic review of prophylactic drug therapy in children with febrile seizures found reduced recurrence rates in children with continuous phenobarbitone (significant reduction at 6, 12, and 24 months, but not at 18 or 72 months of follow-up) or intermittent diazepam (significant reduction at 12, 24, 36, and 48 months but not at 60-72 months).…”

Convulsión febril simple

“…Los cambios en el comportamiento pueden ocurrir en 20% a 40% de los pacientes y pueden ser tan graves que exigen la interrupción del fármaco. [39][40][41][42][43] Fenitoína: no ha demostrado ser eficaz en la prevención de la recurrencia de las CFS, incluso cuando se encuentra en el rango terapéutico. 44,45 Valproatos: el ácido valproico parece tan eficaz en la prevención de las CFS recurrentes como el fenobar- bital y bastante más efectivo que el placebo.…”

Behavioral and Psychiatric Adverse Events Associated With Antiepileptic Drugs Commonly Used in Pediatric Patients

“…Identification of potentially relevant articles began with a series of literature searches performed in early 2004 using Figure 1. Antiepileptic drug use in pediatric epilepsy patients aged 0 through 19 years.' CBZ = carbamazepine; GBP = gabapentin; LEV = levetiracetam; LTG = lamotrigine; OXC = oxcarbazepine; PB = phenobarbital ; PHT = phenytoin; TPM = topiramate; VPA = valproic acid; ZNS = zonisamide.…”

Complex Febrile Seizures: An Update

“…54 In a double-blind trial of children with recurrent and/or CFS, only two (10%) of the children receiving phenobarbital had recurrences versus 47% of patients treated with carbamazepine, suggesting that carbamazepine is not as effective in preventing recurrences as phenobarbital. 55 Intermittent oral levetiracetam was found in one study to be efficacious in preventing febrile seizure recurrence with minimal side effects. 56 A recent systematic review of prophylactic drug therapy in children with febrile seizures found reduced recurrence rates in children with continuous phenobarbitone (significant reduction at 6, 12, and 24 months, but not at 18 or 72 months of follow-up) or intermittent diazepam (significant reduction at 12, 24, 36, and 48 months but not at 60-72 months).…”

Convulsión febril simple

“…Los cambios en el comportamiento pueden ocurrir en 20% a 40% de los pacientes y pueden ser tan graves que exigen la interrupción del fármaco. [39][40][41][42][43] Fenitoína: no ha demostrado ser eficaz en la prevención de la recurrencia de las CFS, incluso cuando se encuentra en el rango terapéutico. 44,45 Valproatos: el ácido valproico parece tan eficaz en la prevención de las CFS recurrentes como el fenobar- bital y bastante más efectivo que el placebo.…”

Behavioral and Psychiatric Adverse Events Associated With Antiepileptic Drugs Commonly Used in Pediatric Patients

“…Identification of potentially relevant articles began with a series of literature searches performed in early 2004 using Figure 1. Antiepileptic drug use in pediatric epilepsy patients aged 0 through 19 years.' CBZ = carbamazepine; GBP = gabapentin; LEV = levetiracetam; LTG = lamotrigine; OXC = oxcarbazepine; PB = phenobarbital ; PHT = phenytoin; TPM = topiramate; VPA = valproic acid; ZNS = zonisamide.…”

Complex Febrile Seizures: An Update

“…54 In a double-blind trial of children with recurrent and/or CFS, only two (10%) of the children receiving phenobarbital had recurrences versus 47% of patients treated with carbamazepine, suggesting that carbamazepine is not as effective in preventing recurrences as phenobarbital. 55 Intermittent oral levetiracetam was found in one study to be efficacious in preventing febrile seizure recurrence with minimal side effects. 56 A recent systematic review of prophylactic drug therapy in children with febrile seizures found reduced recurrence rates in children with continuous phenobarbitone (significant reduction at 6, 12, and 24 months, but not at 18 or 72 months of follow-up) or intermittent diazepam (significant reduction at 12, 24, 36, and 48 months but not at 60-72 months).…”

Convulsión febril simple

“…Los cambios en el comportamiento pueden ocurrir en 20% a 40% de los pacientes y pueden ser tan graves que exigen la interrupción del fármaco. [39][40][41][42][43] Fenitoína: no ha demostrado ser eficaz en la prevención de la recurrencia de las CFS, incluso cuando se encuentra en el rango terapéutico. 44,45 Valproatos: el ácido valproico parece tan eficaz en la prevención de las CFS recurrentes como el fenobar- bital y bastante más efectivo que el placebo.…”