2008
DOI: 10.1007/s10620-008-0277-z
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Abstract: The function of the small intestine is to a large degree mechanical, and it has the capability of deforming its shape by generating phasic (short-lasting) and tonic (sustained) contraction of the smooth muscle layers. The aim of this study was to obtain phasic and tonic stress-strain (normalized force-length) curves during distension of isolated rat jejunum and ileum (somewhat similar to the isometric length-tension diagram known from in vitro studies of muscle strips). We hypothesized that the circumferential… Show more

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Cited by 6 publications
(9 citation statements)
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“…In accordance with our previous study [22], the passive circumferential stress increased when the intestine was stretched longitudinally. Longitudinal stretching caused the active circumferential stress to decrease (data not shown).…”
Section: Resultssupporting
confidence: 93%
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“…In accordance with our previous study [22], the passive circumferential stress increased when the intestine was stretched longitudinally. Longitudinal stretching caused the active circumferential stress to decrease (data not shown).…”
Section: Resultssupporting
confidence: 93%
“…The length-tension diagrams known from physiological and pharmacological studies of smooth muscle strips in vitro [19, 26] can be reproduced in intact segment of intestine in vitro as shown in the present and previous studies [22]. From a biomechanical standpoint, phasic and tonic stress-strain data are required for evaluation of smooth muscle mechanical function in intact intestinal segments.…”
Section: Discussionmentioning
confidence: 70%
See 1 more Smart Citation
“…One end of jejunal segment was fixed to the wall of the tissue bath chamber (20.0 mL volume), and the other end was connected to a force-displacement transducer in longitudinal direction. Contractile amplitude of isolated jejunal segments was recorded and identical time-interval of each assay with same start and stop time was chosen to compare the amplitude of contractions before and after drug treatment in all assays [31]. Jejunal segments isolated from CP and DP rats and assayed in normal Krebs buffer were selected as a pair of low-high contractile states.…”
Section: Methodsmentioning
confidence: 99%
“…From biomechanical point of view, muscle mechanical properties must be described in terms of stress and strain, i.e., the force per area and tissue deformation (Zhao et al, 2008(Zhao et al, , 2011. Stress-strain data are important for understanding the mechanical function of remodeled smooth muscle in the diabetic intestine.…”
Section: Discussionmentioning
confidence: 99%