2005
DOI: 10.1007/s00280-004-0912-0 View full text |Buy / Rent full text
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Abstract: The docetaxel-cisplatin combination is active against several tumors including gastric cancer but it is followed by severe myelosuppression. Recent experience with weekly taxanes has demonstrated a mild myelotoxicity with high dose intensity. We investigated in a phase I study a weekly schedule of docetaxel on days 1, 8 and 15 and cisplatin on day 1 every 4 weeks in 19 patients with advanced gastric cancer with no prior chemotherapy. Cohorts of patients were treated with escalating doses of docetaxel (starting… Show more

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“…Cisplatin (cis-diamminedichloro platinum) is a wellknown platinum-based chemotherapeutic agent, which acts as an activator of apoptosis and an inducer of DNA strand breaking through damage (1,2). It is extensively used to treat various types of cancers, including metastatic ovarian, cervical, sarcoma, head and neck, advanced bladder, thyroid, lymph nodes, skin, colorectal, gastric, pancreatic, metastatic testicular and small-cell lung tumors, either alone or in combination with other anticancer drugs (3)(4)(5)(6)(7)(8)(9). Unfortunately, the use of this compound is generally limited by its side effects.…”
Section: Introductionmentioning
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“…Cisplatin (cis-diamminedichloro platinum) is a wellknown platinum-based chemotherapeutic agent, which acts as an activator of apoptosis and an inducer of DNA strand breaking through damage (1,2). It is extensively used to treat various types of cancers, including metastatic ovarian, cervical, sarcoma, head and neck, advanced bladder, thyroid, lymph nodes, skin, colorectal, gastric, pancreatic, metastatic testicular and small-cell lung tumors, either alone or in combination with other anticancer drugs (3)(4)(5)(6)(7)(8)(9). Unfortunately, the use of this compound is generally limited by its side effects.…”
Section: Introductionmentioning
“…Taxanes – paclitaxel and semisynthetic docetaxel (DT) – are approved as first-line treatment for non-small cell lung cancer (NSCLC) [6,7], breast [8,9] and ovarian [10] carcinomas and are also used in the treatment of numerous other malignancies [11,12,13,14,15]. Paclitaxel is a natural alkaloid isolated from Taxus brevifolia, whereas DT is a semi-synthetic compound produced from 10-deacetylbaccatin III found in Taxus baccata [16].…”
Section: Introductionmentioning
“…One case of septic shock has been reported in a patient receiving docetaxel for a colangiocarcinoma 6 as well as in 3 patients treated with docetaxel for advanced or recurrent gastric cancer. 7,8 In a review of clinical trials with docetaxel for metastatic breast cancer, 6 cases of ischemic colitis were identified, two of them were fatal. 9 …”
Section: Discussionmentioning