Phase I trial of CG53135-05 to prevent mucositis in patients undergoing high-dose chemotherapy (HDCT) and autologous peripheral blood stem cell transplantation (PBSCT)

Relationship between Animal Models and Clinical Research: Using Mucositis as a Practical Example

“…Velafermin has previously been shown to have activity in models of ulcerative colitis [77] and oral mucosal damage following cytotoxic insult [81] . Recent results from a Phase I clinical trial investigating velafermin have indicated that it is well tolerated following intravenous administration [82] and these results have led to Phase II clinical trials, which are now under way.…”