Archives of Otolaryngology - Head and Neck Surgery
 1990
DOI: 10.1001/archotol.1990.01870110043004
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Phase I-II Study of Advanced Head and Neck Squamous Cell Carcinoma Patients Treated With Recombinant Human Interferon Gamma

William J. Richtsmeier
1
,
Wayne M. Koch2,
William P. McGuire3
et al.
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Cited by 50 publications

(23 citation statements)
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“…It has been reported that the production of several cytokines including interferon (IFN)-α, IFN-β, and IFN-γ, interleukin (IL)-1, IL-2, tumor necrosis factor (TNF)-α, and granulocyte-macrophage colony-stimulating factor was induced after human blood, heparinized platelet-rich plasma, and Ficoll-purified blood mononuclear cells were ozonated [ 26 , 27 , 28 , 29 ]. Previous reports have indicated that cytokines inhibit both tumor growth and metastasis [ 30 , 31 , 32 , 33 , 34 ]. Therefore, cytokines may also participate in the growth restraint of tumors.…”
Section: Results
mentioning
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…It has been reported that the production of several cytokines including interferon (IFN)-α, IFN-β, and IFN-γ, interleukin (IL)-1, IL-2, tumor necrosis factor (TNF)-α, and granulocyte-macrophage colony-stimulating factor was induced after human blood, heparinized platelet-rich plasma, and Ficoll-purified blood mononuclear cells were ozonated [ 26 , 27 , 28 , 29 ]. Previous reports have indicated that cytokines inhibit both tumor growth and metastasis [ 30 , 31 , 32 , 33 , 34 ]. Therefore, cytokines may also participate in the growth restraint of tumors.…”
Section: Results
mentioning
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…Used in the perioperative period, peritumoral lymph node injection of IL‐2 resulted in improved disease free survival in multivariate analysis 186. Systemic injection of IFN‐γ, along with the related IFN‐α, as adjuvant therapies have resulted in variable clinical efficacies 187–189. Intratumoral injection of IL‐12 resulted in increased IFN‐γ, NK cell recruitment, and a Th2 to Th1 cytokine profile switch in tumor draining lymph nodes 190…”
Section: Discussion
mentioning
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…There are multiple reports of malignant conversion of benign papillomatous lesions following radiotherapy (4,5,7,10,11). There had been previous reports of the response of HPV-induced lesions to interferon in both the cervix and respiratory tract (12)(13)(14).…”
Section: Discussion
mentioning
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
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