2006
DOI: 10.1007/s00280-006-0203-z View full text |Buy / Rent full text
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Abstract: The absorption and elimination of thalidomide are not significantly different in HCC patients with compensated or decompensated hepatic dysfunction.

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“…The best timing of radiation sensitization by thalidomide demonstrated in preclinical study was administering thalidomide (200 mg/kg) 2 days before RT when an increased initial slope and peak enhancement of the DCEMRI study with enhanced perfusion, reduced interstitial fluid pressure, and reoxygenation of mouse tumors were found [27]. In the present study, the strategy of 3-day thalidomide before RT began was referred to the preclinical data and to achieving a steady serum level [16]. Furthermore, with low-dose thalidomide, a significant suppression of serum bFGF in the concomitant group during RT was also noted [15].…”
Section: Discussionmentioning
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“…The best timing of radiation sensitization by thalidomide demonstrated in preclinical study was administering thalidomide (200 mg/kg) 2 days before RT when an increased initial slope and peak enhancement of the DCEMRI study with enhanced perfusion, reduced interstitial fluid pressure, and reoxygenation of mouse tumors were found [27]. In the present study, the strategy of 3-day thalidomide before RT began was referred to the preclinical data and to achieving a steady serum level [16]. Furthermore, with low-dose thalidomide, a significant suppression of serum bFGF in the concomitant group during RT was also noted [15].…”
Section: Discussionmentioning
“…A dose of 100 mg twice daily was given starting 3 days before RT to achieve a steady serum level [16].…”
Section: Methodsmentioning
“…Twentyfour patients were enrolled and received concomitant thalidomide and radiation. Thalidomide was prescribed at a dose of 100 mg twice daily starting three days before radiotherapy to achieve a steady serum level [94] . The clinical outcomes, cytokine and DCEMRI studies were compared with patients receiving radiotherapy alone.…”
Section: Incorporating Thalidomide Into Radiotherapy For Hcc: Cytokinmentioning
“…46) Other Factors Effects of liver or kidney dysfunction: The absorption and elimination of thalidomide are not significantly different in patients with hepatic dysfunction. 47) Thalidomide is mainly hydrolyzed and passively excreted, and its pharmacokinetics are not expected to be altered in patients with impaired liver or kidney function. 48) The inter-and intra-patient variability in liver or kidney dysfunction was low.…”
Section: Cyps and Transportersmentioning