Phase composition, mechanical performance and in vitro biocompatibility of hydraulic setting calcium magnesium phosphate cement

Klammert, Uwe; Reuther, T.; Blank, Melanie; Reske, Isabelle; Barralet, Jake E.; Grover, Liam M.; Kübler, Alexander C.; Gbureck, Uwe

doi:10.1016/j.actbio.2009.10.021

Cited by 81 publications

(96 citation statements)

References 23 publications

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“…For MCPCs, the HA peaks shifted toward wide angles, indicating that the formation of Mg-substituted hydroxyapatite (MgHA). Meanwhile, several additional peaks corresponding to the beta-TCP and crystalline magnesium phosphate (Mg 3 (PO 4 ) 2 ) could also be observed, which could be attributed to the hydration of magnesium phosphate cement [23,25,26]. Specifically, 5MCPC exhibited a similar composition phase with CPC except slight MgHA and Mg 3 (PO 4 ) 2 (~5%).…”

Section: Physicochemical Properties Of the Mcpcsmentioning

confidence: 86%

Magnesium modification of a calcium phosphate cement alters bone marrow stromal cell behavior via an integrin-mediated mechanism

et al. 2015

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Section: Physicochemical Properties Of the Mcpcsmentioning

confidence: 86%

Magnesium modification of a calcium phosphate cement alters bone marrow stromal cell behavior via an integrin-mediated mechanism

et al. 2015

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“…Recent studies into magnesium phosphates have been conducted due to higher strengths and faster resorption rates of these cements. Magnesium phosphate cement or ceramic compositions explored to date include [8,[24][25][26][27][28] .…”

Section: A N U S C R I P Tmentioning

confidence: 99%

Systematic Assessment of Synthesized Tri-magnesium Phosphate Powders (Amorphous, Semi-crystalline and Crystalline) and Cements for Ceramic Bone Cement Applications

Ostrowski

Sharma

Roy

et al. 2015

Journal of Materials Science & Technology

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“…Nonetheless, the major limitations of BrC are local decrease in pH and its quick setting properties [5,13,14,15]. Several modifiers like sodium hydrogen phosphate, compounds of sulfates and citrates, as well as various metal ions have been added to modulate the setting time of BrCs [1,16,17,18]. …”

Section: Introductionmentioning

confidence: 99%

IGF-loaded silicon and zinc doped brushite cement: physico-mechanical characterization andin vivoosteogenesis evaluation

Vahabzadeh

Bandyopadhyay

Bose

et al. 2015

Integrative Biology

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Dopants play critical roles in controlling the physical, mechanical, degradation kinetics, and in vivo properties of calcium phosphates. The aim of the present study was to evaluate the effects of Silicon (Si) and Zinc (Zn) dopants on physico-mechanical, and in vivo osteogenesis properties of brushite cements (BrCs) alone and in combination with insulin like growth factor 1(IGF-1). Although addition of 0.5 wt.% Si did not alter the setting time, β-TCP content, and compressive strength of BrCs significantly, 0.25 wt. % Zn incorporation was accompanied by a significant decrease in mechanical strength from 4.78±0.21 MPa for pure BrC to 3.78±0.59 MPa and 3.28±0.22 MPa for Zn-BrC and Si/Zn-BrC, respectively. The in vivo bone regeneration properties of doped BrCs alone and in combination with IGF-1 were assessed and compared using chronological radiography, histology, scanning electron microscopy and fluorochrome labeling after 2 and 4 months post implantation in rabbit femoral defect model. Based on different in vivo characterization, better osteogenesis and vasculogenesis was observed for Si-BrC and Si/Zn-BrC, whereas moderate bone regeneration was found in Zn-BrC as compared to pure BrCs. Excellent bone regeneration was observed when doped BrCs were combined with IGF-1. Our findings signify that addition of Si and/or Zn alters the physico-mechanical properties of BrCs and promotes the early stage in vivo osseointegration and bone remodeling properties. Moreover, addition of IGF-1 further improved the performance of BrCs in terms of bone regeneration in animal model.

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Phase composition, mechanical performance and in vitro biocompatibility of hydraulic setting calcium magnesium phosphate cement

Cited by 81 publications

References 23 publications

Magnesium modification of a calcium phosphate cement alters bone marrow stromal cell behavior via an integrin-mediated mechanism

Magnesium modification of a calcium phosphate cement alters bone marrow stromal cell behavior via an integrin-mediated mechanism

Systematic Assessment of Synthesized Tri-magnesium Phosphate Powders (Amorphous, Semi-crystalline and Crystalline) and Cements for Ceramic Bone Cement Applications

IGF-loaded silicon and zinc doped brushite cement: physico-mechanical characterization andin vivoosteogenesis evaluation

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