Veronique Bodart, Virginia Anastassov, Marilyn C. Darkes, Stefan R. Idzan, Jean Labrecque, Gloria Lau, Renee M. Mosi, Kathleen S. Neff, Kim L. Nelson, Melanie C. Ruzek, Ketan Patel, Zefferino Santucci, Robert Scarborough, Rebecca S.Y. Wong et al.
Abstract:CXCR4 is widely expressed in multiple cell types, and is involved in neonatal development, hematopoiesis, and lymphocyte trafficking and homing. Disruption of the CXCL12/CXCR4 interaction has been implicated in stem cell mobilization. Additionally CXCR4 is a co-receptor for HIV. Selective small molecule antagonists of CXCR4 therefore have therapeutic potential. AMD3465 is an N-pyridinylmethylene monocyclam CXCR4 antagonist which can block infection of T-tropic, CXCR4-using HIV. Using the CCRF-CEM T-cell line w…
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