Pharmacology and Toxicology of the Cornea

Effect of Deuterium Oxide on Local Anesthetic Activity of Procaine

“…At pH values below 7.0 the per cent protection was low. This in agreement with the findings of Hind and Goyan ( 3 ) and Swan (10) who showed that at a pH below 7.0 the per cent of free base is less than 1%. Poor anesthetic activity is expected since it is only the free base which is capable of producing this effect.…”

Effect of Deuterium Oxide on Local Anesthetic Activity of Procaine

“…At pH values below 7.0 the per cent protection was low. This in agreement with the findings of Hind and Goyan ( 3 ) and Swan (10) who showed that at a pH below 7.0 the per cent of free base is less than 1%. Poor anesthetic activity is expected since it is only the free base which is capable of producing this effect.…”

Stability of Aqueous Solutions Commonly Employed in the Treatment of Primary Glaucoma

“…Swan and White (119) observed that strong hypertonic solutions produced epithelial damage upon prolonged contact with the cornea. Swan (115) says that the addition of nonmedicament solutes to make ordinary eyedrops isotonic is unnecessary and increases the danger of the pharmacist making an error in the preparation of the prescription. If for some reason it is imperative that the osmotic pressure be accurately adjusted, reference may be made to Nicola's tables (83) or to the isotonic collyria preparation method as developed by Mellen (132) and referred to these tendencies as the lawv of "relative affinities."…”

Effect of Deuterium Oxide on Local Anesthetic Activity of Procaine

“…At pH values below 7.0 the per cent protection was low. This in agreement with the findings of Hind and Goyan ( 3 ) and Swan (10) who showed that at a pH below 7.0 the per cent of free base is less than 1%. Poor anesthetic activity is expected since it is only the free base which is capable of producing this effect.…”

Stability of Aqueous Solutions Commonly Employed in the Treatment of Primary Glaucoma

“…Swan and White (119) observed that strong hypertonic solutions produced epithelial damage upon prolonged contact with the cornea. Swan (115) says that the addition of nonmedicament solutes to make ordinary eyedrops isotonic is unnecessary and increases the danger of the pharmacist making an error in the preparation of the prescription. If for some reason it is imperative that the osmotic pressure be accurately adjusted, reference may be made to Nicola's tables (83) or to the isotonic collyria preparation method as developed by Mellen (132) and referred to these tendencies as the lawv of "relative affinities."…”

Effect of Deuterium Oxide on Local Anesthetic Activity of Procaine

“…At pH values below 7.0 the per cent protection was low. This in agreement with the findings of Hind and Goyan ( 3 ) and Swan (10) who showed that at a pH below 7.0 the per cent of free base is less than 1%. Poor anesthetic activity is expected since it is only the free base which is capable of producing this effect.…”

Stability of Aqueous Solutions Commonly Employed in the Treatment of Primary Glaucoma

“…Swan and White (119) observed that strong hypertonic solutions produced epithelial damage upon prolonged contact with the cornea. Swan (115) says that the addition of nonmedicament solutes to make ordinary eyedrops isotonic is unnecessary and increases the danger of the pharmacist making an error in the preparation of the prescription. If for some reason it is imperative that the osmotic pressure be accurately adjusted, reference may be made to Nicola's tables (83) or to the isotonic collyria preparation method as developed by Mellen (132) and referred to these tendencies as the lawv of "relative affinities."…”