Pharmacologically bio-relevant N-functionalized homo-binuclear macrocyclic complexes: synthesis, spectral studies, biological screening, HSA binding, and molecular docking

Bano, Nausheen; Rauf, Mohd Ahmar; Owais, Mohammad; Shakir, Mohammad

doi:10.1080/24701556.2019.1661443

Cited by 4 publications

(1 citation statement)

References 67 publications

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“…Some bio-efficient macrocycle complexes, [M 2 (bmc4)Cl 4 ]·nH 2 O ( 57 ), (M: Co, Ni, Cu, Zn; bmc4: 1,1′-biphenyl-bis(1,6,9,14-tetrahydro-3,4;11,12-diphenyl-1,6,9,14-tetraazacyclo hexadecane were also designed as biofilm inhibitors on S. aureus , and among them, the Cu(II) complex displayed good potential [ 132 ].…”

Section: Complexes With Antibiofilm Activitymentioning

confidence: 99%

Metal Complexes—A Promising Approach to Target Biofilm Associated Infections

2022

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Microbial biofilms are represented by sessile microbial communities with modified gene expression and phenotype, adhered to a surface and embedded in a matrix of self-produced extracellular polymeric substances (EPS). Microbial biofilms can develop on both prosthetic devices and tissues, generating chronic and persistent infections that cannot be eradicated with classical organic-based antimicrobials, because of their increased tolerance to antimicrobials and the host immune system. Several complexes based mostly on 3D ions have shown promising potential for fighting biofilm-associated infections, due to their large spectrum antimicrobial and anti-biofilm activity. The literature usually reports species containing Mn(II), Ni(II), Co(II), Cu(II) or Zn(II) and a large variety of multidentate ligands with chelating properties such as antibiotics, Schiff bases, biguanides, N-based macrocyclic and fused rings derivatives. This review presents the progress in the development of such species and their anti-biofilm activity, as well as the contribution of biomaterials science to incorporate these complexes in composite platforms for reducing the negative impact of medical biofilms.

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Section: Complexes With Antibiofilm Activitymentioning

confidence: 99%