Pharmacological treatment of cocaine dependence: a systematic review

Lima, Maurí­cio Silva de; Soares, Bernardo; Reisser, Anelise Alves Pereira; Farrell, Michael

doi:10.1046/j.1360-0443.2002.00209.x

Cited by 158 publications

(107 citation statements)

References 50 publications

(51 reference statements)

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“…Attrition in cocaine treatment trials is a problem across treatment modalities. Pharmacologic treatment trials for cocaine dependence report dropout rates of 0-84% (de Lima et al, 2004). Psychotherapy treatment trials for cocaine dependence report dropout rates of 29-41% (Kang et al, 1991;Simpson et al, 1999).…”

Section: Introductionmentioning

confidence: 99%

Performance on the Stroop Predicts Treatment Compliance in Cocaine-Dependent Individuals

Streeter

Terhune

Whitfield

et al. 2007

Neuropsychopharmacol

167

127

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Treatment dropout is a problem of great prevalence and stands as an obstacle to recovery in cocaine-dependent (CD) individuals. Treatment attrition in CD individuals may result from impairments in cognitive control, which can be reliably measured by the Stroop color-word interference task. The present analyses contrasted baseline performance on the color-naming, word-reading, and interference subtests of the Stroop task in CD subjects who completed a cocaine treatment trial (completers: N ¼ 50) and those who dropped out of the trial before completion (non-completers: N ¼ 24). A logistic regression analysis was used to predict trial completion using three models with the following variables: the Stroop task subscale scores (Stroop model); the Hamilton depression rating scale (HDRS) scores (HDRS model); and both the Stroop task subscale scores and HDRS scores (Stroop and HDRS model). Each model was able to significantly predict group membership (completers vs non-completers) better than a model based on a simple constant (HDRS model p ¼ 0.02, Stroop model p ¼ 0.006, and Stroop and HDRS model p ¼ 0.003). Models using the Stroop preformed better than the HDRS model. These findings suggest that the Stroop task can be used to identify cocaine-dependent subjects at risk for treatment dropout. The Stroop task is a widely available, reliable, and valid instrument that can be easily employed to identify and tailor interventions of at risk individuals in the hope of improving treatment compliance.

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Section: Introductionmentioning

confidence: 99%

Performance on the Stroop Predicts Treatment Compliance in Cocaine-Dependent Individuals

Streeter

Terhune

Whitfield

et al. 2007

Neuropsychopharmacol

167

127

View full text Add to dashboard Cite

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“…Illicit psychostimulant abuse, and in particular cocaine, represents a serious social and health concern in many countries, inducing significant mortality and morbidity (de Lima et al, 2002;O'Brien and Anthony, 2005). There is, however, no effective pharmacological treatment available for cocaine dependence (Gawin and Ellinwood, 1989;Jaffe et al, 1989;Stewart, 2000;de Lima et al, 2002;Soares et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

“…There is, however, no effective pharmacological treatment available for cocaine dependence (Gawin and Ellinwood, 1989;Jaffe et al, 1989;Stewart, 2000;de Lima et al, 2002;Soares et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

“…Given the link between cocaine's addictive properties and DA systems, strategies for the treatment of cocaine addiction were mainly focused on direct targeting of DA transporter or receptors (Morgan et al, 1997;Pilla et al, 1999;de Lima et al, 2002;van den Brink and van Ree, 2003). However, several other neurotransmitter/neuromodulator systems functionally linked to DA neurons within the motivational circuit may also contribute to the complex regulations underlying cocaine dependence (Dewey et al, 1998;de Vries et al, 2001;Sarnyai et al, 2001;Kreek et al, 2002;Beinfeld, 2003;Baptista et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

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Neurotensin Receptor Antagonist Administered during Cocaine Withdrawal Decreases Locomotor Sensitization and Conditioned Place Preference

Felszeghy

Espinosa

Scarna

et al. 2007

Neuropsychopharmacol

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Chronic use of psychostimulants induces enduringly increased responsiveness to a subsequent psychostimulant injection and sensitivity to drug-associated cues, contributing to drug craving and relapse. Neurotensin (NT), a neuropeptide functionally linked to dopaminergic neurons, was suggested to participate in these phenomena. We and others have reported that SR 48692, an NT receptor antagonist, given in pre-or cotreatments with cocaine or amphetamine, alters some behavioral effects of these drugs in rats. However, its efficacy when applied following repeated cocaine administration remains unknown. We, therefore, evaluated the ability of SR 48692, administered after a cocaine regimen, to interfere with the expression of locomotor sensitization and conditioned place preference (CPP) in rats. We demonstrated that the expression of locomotor sensitization, induced by four cocaine injections (15 mg/kg, i.p.) every other day and a cocaine challenge 1 week later, was attenuated by a subsequent 2-week daily administration of SR 48692 (1 mg/kg, i.p.). Furthermore, the expression of cocaine-induced CPP was suppressed by a 10-day SR 48692 treatment started after the conditioning period (four 15 mg/kg cocaine injections every other day). Taken together, our data show that a chronic SR 48692 treatment given after a cocaine regimen partly reverses the expression of locomotor sensitization and CPP in the rat, suggesting that NT participates in the maintenance of these behaviors. Our results support the hypothesis that targeting neuromodulatory systems, such as the NT systems may offer new strategies in the treatment of drug addiction.

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“…Effective agonist and antagonist pharmacotherapies as well as symptomatic treatments exist for opioid dependence, but neither agonists nor antagonists have been approved as uniquely effective for treatment of stimulant abuse or dependence (Grabowski, Shearer, Merrill, & Negus, 2004). There is no current evidence supporting the clinical use of carbamazepine (Tegretol), antidepressants, dopamine agonists (drugs commonly used to treat Parkinson's and Restless Leg Syndrome), disulfiram (Antabuse), mazindol (an experimental anorectic), phenytoin (Dilantin), nimodipine (Nimotop), lithium, and other pharmacological agents in the treatment of cocaine dependence (de Lima, de Oliveira Soares, Reisser, & Farrell, 2002;Venneman et al, 2006). Because no proven effective pharmacological interventions are available for cocaine addiction or for methamphetamine addiction, treatment of stimulant addiction has to rely on existing CBTs or CBT combined with other biobehavioral approaches (Van den Brink & van Ree, 2003).…”

Section: Clinical Considerations: Cognitive-behavioral and Neurofeedbmentioning

confidence: 99%

EEG Biofeedback as a Treatment for Substance Use Disorders: Review, Rating of Efficacy and Recommendations for Further Research

Sokhadze¹,

Cannon²,

Trudeau³

2008

Journal of Neurotherapy

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Pharmacological treatment of cocaine dependence: a systematic review

Cited by 158 publications

References 50 publications

Performance on the Stroop Predicts Treatment Compliance in Cocaine-Dependent Individuals

Performance on the Stroop Predicts Treatment Compliance in Cocaine-Dependent Individuals

Neurotensin Receptor Antagonist Administered during Cocaine Withdrawal Decreases Locomotor Sensitization and Conditioned Place Preference

EEG Biofeedback as a Treatment for Substance Use Disorders: Review, Rating of Efficacy and Recommendations for Further Research

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