Pharmacological treatment for Buerger's disease

Cacione, Daniel G; Macedo, Cristiane R; Novaes, Frederico do Carmo; Baptista-Silva, Jose CC

doi:10.1002/14651858.cd011033.pub4

Cited by 18 publications

(19 citation statements)

References 32 publications

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“…[25][26][27] Particularly in refractory courses, additional administration of rheologics such as prostacyclin analogues can also be given. 28 Concomitant analgesic therapy is usually necessary according to World Health Organization recommendations.…”

Section: Therapymentioning

confidence: 99%

“…In addition, an accompanying rheological therapy with low-molecular-weight heparin or direct oral anticoagulants such as rivaroxaban is often useful. [28][29][30] Recent advances in clinical understanding of the mechanism of calciphylaxis have identified promising potential therapeutic targets. 48 Treatment basically consists of three approaches: reversal of vessel-wall calcification to restore blood flow including sodium thiosulfate as a calcium chelator 48 and vitamin K supplementation; amelioration of calciphylaxis risk factors and optimization of wound care, including appropriate debridement; and, if appropriate, hyperbaric oxygen therapy.…”

Section: Therapymentioning

confidence: 99%

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Inflammatory skin diseases and wounds

Dissemond¹,

Romanelli

2022

Br J Dermatol

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Inflammatory wounds of the skin can be caused by many different diseases. Of particular importance here are the very heterogeneous groups of vasculitides and vasculopathies. These are usually interdisciplinary relevant diseases that require extensive diagnostics in specialized centres. Clinically, these inflammatory wounds present as very painful ulcers that develop from necrosis and are surrounded by erythematous livid borders. The healing process is often difficult and protracted. Moreover, it considerably impairs the quality of life of the affected patients. In addition to clinical evaluation, histopathological examination of biopsies taken as early as possible is particularly important in diagnosis. Numerous differential diagnoses must be ruled out. Therapeutically, in addition to the often necessary systemic therapies, which include immunosuppressants (immunomodulating drugs and/or rheologics), appropriate topical wound treatment, usually in combination with compression therapy, should always be considered. Whenever possible, the causative factors should be diagnosed early and avoided or treated.

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Section: Therapymentioning

confidence: 99%

Section: Therapymentioning

confidence: 99%

Inflammatory skin diseases and wounds

Dissemond¹,

Romanelli

2022

Br J Dermatol

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“…The choice of smart dressings should follow the aforementioned principles. For venous ulcers, rheological treatment with sulodexide may help the ulcer to heal, and for an arterial aetiology prostacyclin and pentoxifylline may be effective, and the latter may have a beneficial effect on venous ulcers as well [32][33][34][35].…”

Section: Chronic Leg Ulcers: Characteristics and Treatment Optionsmentioning

confidence: 99%

Chronic wounds in the elderly: Decubitus, leg ulcers, and ulcers of rare aetiology

Bánvölgyi

Görög

Gadó

et al. 2022

DHS

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The ageing processes, primarily after the age of 60, bring about a number of important changes that affect the skin’s protective function. These changes directly and indirectly increase its vulnerability and impair its ability to heal. Hence, the incidence of chronic wounds increases in the elderly population. Dry skin, often accompanied by itching and consequent scratching, can lead to the development of wounds. The skin’s ability to regenerate itself is also impaired by the atrophy that affects all the three layers of the skin, the epidermis, dermis, and subcutis. The deterioration of vascularisation and innervation increases the chance of ulcer formation and impaired healing of existing wounds. Together these lead to the development of chronic lower limb ulcers in elderly patients or decubitus in older bedridden patients. Bedsores are more likely to develop in older patients with reduced body weight due to their decreased amount of adipose tissue capable of pressure-relieving. This latter negative tendency may be exacerbated by the presence of reduced mobility, impaired muscle strength, and frequent incontinence. In all respects, the propensity to heal is worse than in younger age, thus in many cases a chronic process is expected, and in some cases halting the progression may be a significant outcome. Ulcers of rare aetiology can occur at any age, so pyoderma gangrenosum, vasculitis, and other ulcers with rare aetiology in the elderly population should also be considered.

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“…These burdensome detection procedures are time-consuming and hinder the quick and efficient treatment of TAO. Additionally, one effective treatment for TAO is the cessation of smoking accompanied by drug treatment [ 5 ], such as vascular dilators (cilostazol), antiplatelet drugs (clopidogrel), and thrombolytic drugs (urokinase) [ 6 ]. However, no long-term benefit of these drugs has been confirmed [ 7 ], although they contribute to a number of side effects.…”

Section: Introductionmentioning

confidence: 99%

Integrated analysis of long non-coding RNA-microRNA-mRNA competing endogenous RNAregulatory networks in thromboangiitis obliterans

et al. 2021

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Thromboangiitis obliterans (TAO) is a non-atherosclerotic, segmental, chronic vascular inflammatory disease. Our aim was to explore the underlying mechanisms of long non-coding RNA (lncRNA)-related competing endogenous RNAs (ceRNAs) in TAO. Six blood samples were collected from patients with TAO and healthy individuals (three for each category). Total RNA was extracted from the blood of each participant and sequenced. Differentially expressed lncRNAs (DE-lncRNAs) and miRNAs (DE-miRNAs) were screened, and ceRNA networks associated with TAO were constructed. Thereafter, the genes in the ceRNA network were subjected to functional analyses. Finally, a ceRNA relationship (lncRNA NEAT1-hsa-miR-1-3p-mRNA GNA12) was selected for further validation. Analysis revealed that 347 DE-lncRNAs (150 downregulated and 197 upregulated) and 16 DE-miRNAs (3 downregulated and 13 upregulated) were identified in TAO. Further, TAO-associated ceRNA networks, which included 219 lncRNAs, 6 miRNAs, and 53 mRNAs, were proposed and subjected to gene annotation and pathway analysis. Additionally, NEAT1 and GNA12 levels were significantly upregulated, while miR-1-3p levels were evidently downregulated in TAO patients, as compared with those in healthy controls. Dual luciferase reporter assays showed that NEAT1, miR-1-3p, and GNA12 interacted with each other. We report potential TAO-associated ceRNA regulatory networks and suggest activation of NEAT1/miR-1-3p/GNA12 signaling as a novel mechanism for TAO progression.

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Pharmacological treatment for Buerger's disease

Abstract: Analysis 2.3. Comparison 2 Intravenous prostacyclin analogue (iloprost) versus oral aspirin, Outcome 3 Complete relief of rest pain (4

Cited by 18 publications

References 32 publications

Inflammatory skin diseases and wounds

Inflammatory skin diseases and wounds

Chronic wounds in the elderly: Decubitus, leg ulcers, and ulcers of rare aetiology

Integrated analysis of long non-coding RNA-microRNA-mRNA competing endogenous RNAregulatory networks in thromboangiitis obliterans

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