Pharmacological Studies of Cardamom Oil in Animals

al-Zuhair, H; El-Sayeh, Bahia M.; Ameen, H A; al-Shoora, H

doi:10.1006/phrs.1996.0067

Cited by 122 publications

(69 citation statements)

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“…The contraction of smooth muscle preparations, including rat jejunum, is dependent upon an increase in cytoplasmic free [Ca 2+ ], which activates the contractile elements. The contraction of smooth muscle induced by high K + is dependent, in turn, upon the entry of Ca 2+ into the cells through voltage activated ion channels, while inhibition of high K + -induced contraction results from the prevention of Ca 2+ entry through these channels (Al-Zuhair et al, 1996;Bolton, 1979), a characteristic of calcium channel blockers (CCB). It was observed previously that the antispasmodic constituents present in various medicinal plants mediate their effect usually through a CCB action (Ghayur et al, 2006;Gilani et al, 2006;Shah et al, 2010).…”

Section: Resultsmentioning

confidence: 99%

Antispasmodic effect of Jatropha gossypiifolia is mediated through dual blockade of muscarinic receptors and Ca2+ channels

Silva¹,

Abreu²,

Freire³

et al. 2011

Rev. bras. farmacogn.

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Abstract:The antispasmodic activity of Jatropha gossypiifolia L., Euphorbiaceae, aerial parts was investigated in rodents using the mouse intestinal transit model and acetylcholine (ACh, to 10 -4 M) and calcium (CaCl 2 , 10 -4 to 10 -1 M)-induced contractions of isolated rat jejunum. Similar to atropine (1 mg/kg), oral doses of ethanolic extract (EE) of J. gossypiifolia (500, 1000 and 2000 mg/kg) produced a decrease in intestinal transit (37.6 to 57.1%) when compared with control. The ACh-induced contraction in the jejunum was inhibited by EE (0.5, 1.0 and 2.0 mg/ mL), chloroformic (CF) and aqueous fractions (0.1 and 0.5 mg/mL) and methanolic subfraction (0.05 and 0.25 mg/mL), suggesting an antimuscarinic mechanism. CaCl 2 -induced responses in jejunum were also attenuated in the presence of CF (0.05 and 0.1 mg/mL) implying a direct interference of CF with the influx of calcium ions in the cells. Only the organic fraction of the extract had a calcium-antagonist effect, whereas both chloroformic and aqueous fractions had anticholinergic effect. These results suggest that the antispasmodic effect of J. gossypiifolia may be due a combination of anticholinergic and calcium antagonist mechanisms.

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Section: Resultsmentioning

confidence: 99%

Antispasmodic effect of Jatropha gossypiifolia is mediated through dual blockade of muscarinic receptors and Ca2+ channels

Silva¹,

Abreu²,

Freire³

et al. 2011

Rev. bras. farmacogn.

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“…In medicine it is used to treat gastrointestinal disorders [2]. Despite its wide uses, little information has been reported on their pharmacological properties, which showed antioxidant [3][4] and anti-inflammatory activity [5]. Antimicrobial activity of cardamom was attributed to its essential oil [6][7].…”

Section: Introductionmentioning

confidence: 99%

Hepatoprotective effect of aqueous extract of cardamom against gentamicin induced hepatic damage in rats

Aboubakr

Abdelazem

2015

IJBAS

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The study was designed to evaluate the hepatoprotective activity of aqueous extract of cardamom in acute experimental liver injury induced by gentamicin. Twenty four male albino rats were randomly divided into four groups (six rats in each). Animals of the first group served as control and orally (p.o.) received (1 ml/kg saline). The second experimental group was given gentamicin (80 mg/kg i.p.) for 7 days. Third and fourth groups were given aqueous extract of cardamom (100 and 200 mg/kg p.o.) + gentamicin for 7 days, respectively. The degree of hepatoprotection was measured using serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), bilirubin, albumin, and lipid profile levels. In the acute liver damage induced by gentamicin, cardamom aqueous extracts (100 and 200 mg/kg, p.o.) significantly reduced the elevated serum levels of AST, ALT, bilirubin, cholesterol, triglycerides and low density lipoprotein cholesterol (LDL-chol) in gentamicin induced hepatotoxicity. Also cardamom aqueous extracts (100 & 200 mg/kg, p.o.) significantly increased the lowered serum levels of albumin and high density lipoprotein cholesterol (HDL-chol) in gentamicin induced hepatotoxicity rats. Histopathological examination of the liver tissues supported the hepatoprotection. Our findings concluded that cardamom aqueous extracts possessed hepatoprotective activity against gentamicin induced hepatotoxicity in rats.

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“…37,38) Epidemiological studies have almost confirmed that non steroidal anti-inflammatory drugs reduce the incidence of AD. 39) Foeniculum vulgare, 40) Boerhaavia diffusa, 41) Celastrus paniculatus, 42) Centella asiatica, 43) Cyperus rotundus, 44) Eclipta alba, 45) Elettaria cardamomum, 46) Phyllanthus emblica, 47) Glycyrrhiza glabra, 48) Ocimum sanctum, 49) Piper longum, 50) Zingiber officianale, 51) and Withania somnifera 52) have been proved as anti-inflammatory agents, which might protect from the development of inflammatory lesions in brain.…”

Section: Discussionmentioning

confidence: 99%

Memory Enhancing Activity of Abana: An Indian Ayurvedic Poly-Herbal Formulation

Parle

Mani

2007

JOURNAL OF HEALTH SCIENCE

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The present study was aimed at investigating the effects of Abana, an Ayurvedic herbomineral preparation on memory and brain cholinesterase activity in mice. Drug Abana was administered orally in three doses (50, 100 and 200 mg/kg) for fifteen days to different groups of young and aged mice. Elevated plus maze and passive avoidance apparatus served as the exteroceptive behavioral models for testing memory. Diazepam-, scopolamine-and ageinginduced amnesia served as the interoceptive behavioral models. Brain cholinesterase activity was also estimated. Abana (50, 100 and 200 mg/kg, orally (p.o.)) produced a dose-dependent improvement in memory scores of young and aged mice. Furthermore, it reversed the amnesia induced by scopolamine (0.4 mg/kg, intraperitoneally (i.p.)) and diazepam (1 mg/kg, i.p.). Interestingly, brain cholinesterase activity was reduced by Abana administered orally for 15 days. It may prove to be a useful remedy for the management of Alzheimer's disease.

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Pharmacological Studies of Cardamom Oil in Animals

Cited by 122 publications

References 0 publications

Antispasmodic effect of Jatropha gossypiifolia is mediated through dual blockade of muscarinic receptors and Ca2+ channels

Antispasmodic effect of Jatropha gossypiifolia is mediated through dual blockade of muscarinic receptors and Ca2+ channels

Hepatoprotective effect of aqueous extract of cardamom against gentamicin induced hepatic damage in rats

Memory Enhancing Activity of Abana: An Indian Ayurvedic Poly-Herbal Formulation

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