volume 9, issue 6, P687-697 1975
DOI: 10.1002/jbm.820090613
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Abstract: Aqueous extracts of a PVC transfusion tubing contracted isolated guinea-pig ilea. A pharmacological and chemical study (infrared spectroscopy, gas-liquid chromatography) showed that this was due to extraction of the plasticizer, acetyl N-tributyl citrate (ATBC). The concentrations of ATBC to produce contractions of the isolated guinea-pig ileum (from 1 mug/ml) can be compared with those achieved after recirculating tubing under conditions simulating use (up to 6 mug/ml). In assessing the toxicity of plastic tu…

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