Pharmacological Overview of Galactogogues

Penagos-Tabares, Felipe; Jaramillo, Juliana Victoria Bedoya; Ruiz-Cortés, Zulma Tatiana

doi:10.1155/2014/602894

Cited by 54 publications

(51 citation statements)

References 134 publications

(176 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The influence of stress on plasma oxytocin and prolactin (the hormone essential for the lactation) concentrations on milk production was evaluated in 18 mothers of preterm infants. The results in the neonatal period; furthermore, it supports a good mother-baby relationship [1][2][3]. It has been clearly demonstrated that preterm infants receiving maternal milk have better outcomes, both nutritional (supply of polyunsaturated fat acids and proteins) and non-nutritional (reduced incidence of infections and atopic eczema) [4,5].…”

Section: The Correlation Between Stress and Hypogalactiamentioning

confidence: 87%

“…Physicians need to provide information regarding best practices for breastfeeding and, if necessary, they should indicate methods to support breast Nutrafoods (2015) tion of the myoepithelial cells that surround the alveoli and milk ducts, causing milk ejection; no adverse events), growth hormones (GH; somatotropin, mechanism of action not yet completely known, no adverse events), thyrotrophin-releasing hormone (TRH; stimulation of the secretion of thyroid-stimulating hormone and prolactin by the pituitary gland; some cases of iatrogenic hyperthyroidism and diaphoresis in mothers) and medroxyprogesterone (mechanism of action unknown, no adverse events except amenorrhea) [1,3].…”

Section: The Issue Of Hypogalactiamentioning

confidence: 99%

“…Plants with galactogogue properties include fenu- [3,12]. However, this is an assumption because for most natural products no scientific studies are available that have demonstrated this effect.…”

Section: Natural Galactogoguesmentioning

confidence: 99%

See 2 more Smart Citations

Galactogogues and breastfeeding

Wilińska

Schleußner

2015

Nutrafoods

View full text Add to dashboard Cite

Reduced breast milk production (called hypogalactia) is the most frequent cause of breastfeeding failure. For this reason, physicians need to provide information regarding best practices for breastfeeding and, if necessary, they should indicate methods to support breast milk production, for example the use of galactogogue medications, making sure that these problems do not lead to cessation of breastfeeding. Galactogogues are synthetic or plants molecules able to induce, maintain and increase milk production in women. The most frequently used natural galactogogue products include galega and silymarin. Unfortunately, all herbal extracts are characterised by low solubility with poor bioavailability and for this reason, in order to increase the absorption and efficacy of silymarin, a new formulation was developed and used as a delivery system: Silitidil ® , a phytosome composed of silymarin and phospholipids. Silitidil ® is able to improve the bioavailability of silymarin, in comparison with pure silymarin and micronised silymarin. Moreover, a recently published pharmacological study from Capasso et al. has evaluated the effect of Silitidil ® and the association of Silitidil ® plus Galega officinalis on prolactin blood levels in mature female Wistar rats, versus control and micronised silymarin. Silitidil ® plus Galega officinalis showed improved bioavailability and prolactin plasma levels compared with the oldest formulations of silymarin. Based on available data, this formulation could be considered a safe and effective natural product able to improve daily breast milk production in healthy women after delivery, without affecting milk quality. Breastfeeding: benefits to mothers and newbornsMaternal milk is still considered the optimal feeding for all babies till 1 year of age, because it is a species-specific nourishment for the baby and has a direct impact on growth, development and health Keywords:Breastfeeding woman stimulation of lactation galactogogues 1 3

show abstract

Section: The Correlation Between Stress and Hypogalactiamentioning

confidence: 87%

Section: The Issue Of Hypogalactiamentioning

confidence: 99%

See 1 more Smart Citation

Galactogogues and breastfeeding

Wilińska

Schleußner

2015

Nutrafoods

View full text Add to dashboard Cite

show abstract

“…Previous studies conducted on humans and animals suggested that this species has positive effects on milk secretion because it contains a mixture of flavonolignans. Silybin, the major constituent of silymarin, binds to cytosolic estrogen receptors determining phytoestrogenic activity [48,69,70].…”

Section: Fresh or Dried Leaves Fruitmentioning

confidence: 99%

Ethnobotanical uses of wild taxa as galactagogues in Sicily (Italy)

Geraci

Polizzano²,

Schicchi³

2018

Acta Soc Bot Pol

View full text Add to dashboard Cite

Breastfeeding furnishes optimal nutrition, immune support, and a multitude of health benefits to mothers and newborns. Since ancient times plants have been employed as galactagogues in the folk medicine of many human cultures. In Sicily, a region with great floristic diversity in the Mediterranean area, where a conspicuous pool of species is traditionally used for food and aromatic, cosmetic, handicraft, agricultural, forestry, and medicinal purposes, some people recognize the galactagogue properties of some spontaneous plants.The goal of this study was to identify wild plants with galactagogue properties and vegetable-food remedies traditionally used by women during breastfeeding to increase milk production. It was conducted in the Madonie territory (province of Palermo) by interviewing a sample of 105 people that was divided into three age groups.Ethnobotanical investigations revealed a total of 34 species, belonging to 11 families and 25 genera, used as galactagogues. For each taxon, the parts used, the methods of preparation, and the phytochemical profiles according to the literature were reported. The most represented family was Asteraceae, with 12 genera and 17 species, the majority of which contained latex.The most frequently used parts of the galactagogue plants were leaves (69%) that were mainly eaten as cooked vegetables, raw in salads, or utilized as an infusion tea. The species cited in this study are mainly wild traditional vegetables with high nutritional profiles that could improve the quality and the quantity of the milk produced. The study found that older people represent a precious source of information to help younger people preserve the cultural identity of the territory.

show abstract

“…They concluded that while the volume and composition of milk in poorly nourished women was Bsurprisingly good,^it was also often Bsuboptimal in quantity and in quality…^and noted that limited studies that supplemented such women resulted in improved milk output [138]. A recent overview of galactogogues published in a veterinary journal stated matter-of-factly that BBreastfeeding is influenced by nutritional and nonnutritional factors… that affect milk synthesis and secretion [139].^The idea that diet can make a difference in milk production seems much more acceptable in the animal lactation world than in the human lactation world.…”

Section: Maternal Nutrition: Does It Matter?mentioning

confidence: 99%

Unsolved Mysteries of the Human Mammary Gland: Defining and Redefining the Critical Questions from the Lactation Consultant’s Perspective

Marasco

2014

J Mammary Gland Biol Neoplasia

View full text Add to dashboard Cite

Despite advances in knowledge about human lactation, clinicians face many problems when advising mothers who are experiencing breastfeeding difficulties that do not respond to normal management strategies. Primary insufficient milk production is now being acknowledged, but incidence rates have not been well studied. Many women have known histories of infertility, polycystic ovary syndrome, obesity, hypertension, insulin resistance, thyroid dysfunction, hyperandrogenism or other hormonal imbalances, while others have no obvious risk factors. Some present with obviously abnormal breasts that are pubescent, tuberous/tubular or asymmetric in shape, raising the question of insufficient mammary gland tissue. Other women have breasts that appear within normal limits yet do not lactate normally. Endocrine disruptors may underlie some of these cases but their impact on human milk production has not been well explored. Similarly, any problem with prolactin such as a deficiency in serum prolactin or receptor number, receptor resistance, or poor bioavailability or bioactivity could underlie some cases of insufficient lactation, yet these possibilities are rarely investigated. A weak or suppressed milk ejection reflex, often assumed to be psychosomatic, could be related to thyroid dysfunction or caused by downstream post-receptor pathway problems. In the absence of sufficient data regarding these situations, desperate mothers may turn to non-evidence-based remedies, sometimes at considerable cost and unknown risk. Research targeted to these clinical dilemmas is critical in order to develop evidence-based strategies and increase breastfeeding duration and success rates.

show abstract

Pharmacological Overview of Galactogogues

Cited by 54 publications

References 134 publications

Galactogogues and breastfeeding

Galactogogues and breastfeeding

Ethnobotanical uses of wild taxa as galactagogues in Sicily (Italy)

Unsolved Mysteries of the Human Mammary Gland: Defining and Redefining the Critical Questions from the Lactation Consultant’s Perspective

Contact Info

Product

Resources

About