2011
DOI: 10.1111/j.1369-1600.2010.00310.x View full text |Buy / Rent full text
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Abstract: Growing evidence supports a role for the central nervous system (CNS) neurotransmitter L-glutamate and its metabotropic receptors (mGluRs) in drug addiction in general and alcohol-use disorders in particular. Alcohol dependence, for instance, has a genetic component, and the recent discovery that variations in the gene coding for mGluR7 modulate alcohol consumption further validates involvement of the L-glutamate system. Consequently, increasing interest emerges in developing L-glutamatergic therapies for the … Show more

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“…Presumably this excess glutamate stimulates mGluRs in these brain regions. It is likely (although not yet demonstrated) that ethanol-induced glutamate activity participates in adaptive processes, such as those involved in sensitization, tolerance, withdrawal, and relapse (Bahi, 2011;Bahi et al, 2012;Salling et al, 2008). The receptor basis for these effects is poorly understood.…”
Section: Discussionmentioning
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“…Presumably this excess glutamate stimulates mGluRs in these brain regions. It is likely (although not yet demonstrated) that ethanol-induced glutamate activity participates in adaptive processes, such as those involved in sensitization, tolerance, withdrawal, and relapse (Bahi, 2011;Bahi et al, 2012;Salling et al, 2008). The receptor basis for these effects is poorly understood.…”
Section: Discussionmentioning
“…In contrast, a growing literature surrounding alcohol's interactions with the mGlu7 receptor has emerged over the past few years, and the profile of agonist effects are akin to those described previously for mGlu2/3-receptor agonists. Systemic treatment with the mGlu7 receptor PAM AMN082 was found to reduce voluntary alcohol consumption and preference in C57BL/6 J mice, whereas systemic administration of the mGlu7 inhibitor MMPIP increased behavior on these measures and reversed the effects of AMN082 (e.g., Bahi, 2011;Bahi, Fizia, Dietz, Gasparini, & Flor, 2012). Although daily treatment with AMN082 failed to influence the extinction of an ethanol-conditioned place preference by C57BL/6 J mice, the PAM reduced ethanol-primed reinstatement of place preference, and this effect was again reversed by coadministration of MMPIP (Bahi, 2012).…”
Section: Group 2 and 3 Mglursmentioning
“…However, in contrast with mGluR2/3 stimulation, mGluR7 activation augments glutamate and GABA release (Li et al, 2013). Systemic administration of AMN082 (N,N9-dibenzhydrylethane-1,2-diamine dihydrochloride), a selective mGluR7 agonist, inhibits cocaine intake and cocaine-and heroin-primed reinstatement (Li et al, 2010), as well as ethanol intake and ethanol-primed CPP (Salling et al, 2008;Bahi et al, 2012). Interestingly, microinjection of the mGluR7 agonist AMN082 in Fig.…”
Section: E Group III Metabotropic Glutamate Receptors (Metabotropic mentioning