Pharmacological Manipulation of Cortical Inhibition in the Dorsolateral Prefrontal Cortex

Salavati, Bahar; Rajji, Tarek K.; Zomorrodi, Reza; Blumberger, Daniel M.; Chen, Robert; Pollock, Bruce G.; Daskalakis, Zafiris J.

doi:10.1038/npp.2017.104

Cited by 13 publications

(9 citation statements)

References 56 publications

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“…In addition, the influence of other neurotransmitters, such as dopamine and glutamate, on LII cannot be excluded (Salavati et al . ) and may have contributed to the suppressed firing of neurons in the motor cortex, independent of GABA receptor‐mediated mechanisms.…”

Section: Discussionmentioning

confidence: 99%

Fatigue‐related group III/IV muscle afferent feedback facilitates intracortical inhibition during locomotor exercise

Sidhu

Weavil

Thurston

et al. 2018

The Journal of Physiology

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We investigated the influence of group III/IV muscle afferents in determining corticospinal excitability during cycling exercise and focused on GABA neuron-mediated inhibition as a potential underlying mechanism. Both under control conditions (CTRL) and with lumbar intrathecal fentanyl (FENT) impairing feedback from group III/IV leg muscle afferents, subjects (n = 11) cycled at a comparable vastus-lateralis EMG signal (∼0.26 mV) before (PRE; 100 W) and immediately after (POST; 90 ± 2 W) fatiguing constant-load cycling exercise (80% Wpeak; 221 ± 10 W; ∼8 min). During, PRE and POST cycling, single and paired-pulse (100 ms interstimulus interval) transcranial magnetic stimulations (TMS) were applied to elicit unconditioned and conditioned motor-evoked potentials (MEPs), respectively. To distinguish between cortical and spinal contributions to the MEPs, cervicomedullary stimulations (CMS) were used to elicit unconditioned (CMS only) and conditioned (TMS+CMS, 100 ms interval) cervicomedullary motor-evoked potentials (CMEPs). While unconditioned MEPs were unchanged from PRE to POST in CTRL, unconditioned CMEPs increased significantly, resulting in a decrease in unconditioned MEP/CMEP (P < 0.05). This paralleled a reduction in conditioned MEP (P < 0.05) and no change in conditioned CMEP. During FENT, unconditioned and conditioned MEPs and CMEPs were similar and comparable during PRE and POST (P > 0.2). These findings reveal that feedback from group III/IV muscle afferents innervating locomotor muscle decreases the excitability of the motor cortex during fatiguing cycling exercise. This impairment is, at least in part, determined by the facilitating effect of these sensory neurons on inhibitory GABA intracortical interneurons.

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Section: Discussionmentioning

confidence: 99%

Fatigue‐related group III/IV muscle afferent feedback facilitates intracortical inhibition during locomotor exercise

Sidhu

Weavil

Thurston

et al. 2018

The Journal of Physiology

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“…This region has been suggested to be related the cognitive control of sensorimotor functions (Zhang et al, ), and to be a part of a long‐range association limbic–motor pathway (Rizzo et al, ). Synaptic activity in the limbic circuits is tightly regulated by a relatively small population of GABA inhibitory neurons (Prager, Bergstrom, Wynn, & Braga, ) previously suggested to be involved in P180 genesis (Ferreri, Ponzo, et al, ; Salavati et al, ).…”

Section: Discussionmentioning

confidence: 99%

Maturation changes the excitability and effective connectivity of the frontal lobe: A developmental TMS–EEG study

Määttä

Säïsänen

Kallioniemi

et al. 2019

Human Brain Mapping

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The combination of transcranial magnetic stimulation with simultaneous electroencephalography (TMS–EEG) offers direct neurophysiological insight into excitability and connectivity within neural circuits. However, there have been few developmental TMS–EEG studies to date, and they all have focused on primary motor cortex stimulation. In the present study, we used navigated high‐density TMS–EEG to investigate the maturation of the superior frontal cortex (dorsal premotor cortex [PMd]), which is involved in a broad range of motor and cognitive functions known to develop with age. We demonstrated that reactivity to frontal cortex TMS decreases with development. We also showed that although frontal cortex TMS elicits an equally complex TEP waveform in all age groups, the statistically significant between‐group differences in the topography of the TMS‐evoked peaks and differences in current density maps suggest changes in effective connectivity of the right PMd with maturation. More generally, our results indicate that direct study of the brain's excitability and effective connectivity via TMS–EEG co‐registration can also be applied to pediatric populations outside the primary motor cortex, and may provide useful information for developmental studies and studies on developmental neuropsychiatric disorders.

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“…Specifically, five articles examined SICI, 21,45,[79][80][81]110 13 articles studied LICI, [42][43][44][82][83][84][85][86][87]103,104,108,111 four articles investigated SAI, 46,53,88,89 three articles investigated ICF, 21,45,81 and five articles investigated PAS. [90][91][92][93]109 Additionally, 11 articles examined the pharmacological effects on TEP 80,[101][102][103][104][105][106][107][108][109][110] and eight articles studied technical aspects of TMS-EEG analyses (e.g., artifact reduction). 16,111,[113][114][115][116]124,…”

Section: Resultsmentioning

confidence: 99%

“…Baclofen had no effect on PAS-induced LTP compared to placebo. 108 TMS-EEG neurophysiology for psychiatry PCN Psychiatry and…”

Section: Other Neurotransmissionsmentioning

confidence: 99%

Toward the establishment of neurophysiological indicators for neuropsychiatric disorders using transcranial magnetic stimulation‐evoked potentials: A systematic review

Noda

2019

Psychiatry Clin Neurosci

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Transcranial magnetic stimulation (TMS) can depolarize the neurons directly under the coil when applied to the cerebral cortex, and modulate the neural circuit associated with the stimulation site, which makes it possible to measure the neurophysiological index to evaluate excitability and inhibitory functions. Concurrent TMS and electroencephalography (TMS-EEG) has been developed to assess the neurophysiological characteristics of cortical regions other than the motor cortical region noninvasively. The aim of this review is to comprehensively discuss TMS-EEG research in the healthy brain focused on excitability, inhibition, and plasticity following neuromodulatory TMS paradigms from a neurophysiological perspective. A search was conducted in PubMed to identify articles that examined humans and that were written in English and published by September 2018. The search terms were as follows: (TMS OR 'transcranial magnetic stimulation') AND (EEG OR electroencephalog*) NOT (rTMS OR 'repetitive transcranial magnetic stimulation' OR TBS OR 'theta burst stimulation') AND (healthy). The study presents an overview of TMS-EEG methodology and neurophysiological indices and reviews previous findings from TMS-EEG in healthy individuals. Furthermore, this review discusses the potential application of TMS-EEG neurophysiology in the clinical setting to study healthy and diseased brain conditions in the future. Combined TMS-EEG is a powerful tool to probe and map neural circuits in the human brain noninvasively and represents a promising approach for determining the underlying pathophysiology of neuropsychiatric disorders.

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Pharmacological Manipulation of Cortical Inhibition in the Dorsolateral Prefrontal Cortex

Cited by 13 publications

References 56 publications

Fatigue‐related group III/IV muscle afferent feedback facilitates intracortical inhibition during locomotor exercise

Fatigue‐related group III/IV muscle afferent feedback facilitates intracortical inhibition during locomotor exercise

Maturation changes the excitability and effective connectivity of the frontal lobe: A developmental TMS–EEG study

Toward the establishment of neurophysiological indicators for neuropsychiatric disorders using transcranial magnetic stimulation‐evoked potentials: A systematic review

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